Evidence map›Paper›PMID 17640094›Full record

ArticleElectrophoresis2007

In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications.

Tao Pan, Gina S Fiorini, Daniel T Chiu, Adam T Woolley

Abstract read
In one paragraph

Article in Electrophoresis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tao PanDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602-5700, USA.
Gina S Fiorini
Daniel T Chiu
Adam T Woolley

Funding

Phase-Changing Sacrificial Layer Microfluidics for Enhanced Protein AnalysisR01EB006124 · NIBIB · BRIGHAM YOUNG UNIVERSITY · PI WOOLLEY, ADAM THOMAS · 2006 to 2016
$3.1M
Electromobility Focusing for Separation of ProteinsR01GM064547 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI LEE, MILTON L. · 2003 to 2008
$1.6M
Probing single proteins in nanofabricated bioenvironmentR01GM065293 · NIGMS · UNIVERSITY OF WASHINGTON · PI CHIU, DANIEL T · 2002 to 2006
$1.4M
NIBIB NIH HHS EB006124NIBIB NIH HHS R01 EB006124NIGMS NIH HHS GM064547NIGMS NIH HHS GM065293NIGMS NIH HHS R01 GM064547NIGMS NIH HHS R01 GM065293
6 · The paper itself

Abstract

A new technique for polymer microchannel surface modification, called in-channel atom-transfer radical polymerization, has been developed and applied in the surface derivatization of thermoset polyester (TPE) microdevices with poly(ethylene glycol) (PEG). X-ray photoelectron spectroscopy, electroosmotic flow (EOF), and contact angle measurements indicate that PEG has been grafted on the TPE surface. Moreover, PEG-modified microchannels have much lower and more pH-stable EOF, more hydrophilic surfaces and reduced nonspecific protein adsorption. Capillary electrophoresis separation of amino acid and peptide mixtures in these PEG-modified TPE microchips had good reproducibility. Phosducin-like protein and phosphorylated phosducin-like protein were also separated to measure the phosphorylation efficiency. Our results indicate that PEG-grafted TPE microchips have broad potential application in biomolecular analysis.

Indexed as

AdsorptionAmino AcidsElectrophoresis, MicrochipFluorescein-5-isothiocyanateFluorescent DyesMicrofluidic Analytical TechniquesPeptidesPolyestersPolyethylene GlycolsProteinsAmino AcidsFluorescein-5-isothiocyanateFluorescent DyesPeptidesPolyestersPolyethylene GlycolsProteins

Identifiers

PMID17640094
PMCPMC3269121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.