ArticlePublic health reports (Washington, D.C. : 1974)
Modified directly observed therapy for antiretroviral therapy: a primer from the field.
Article in Public health reports (Washington, D.C. : 1974). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ART Adherence: Enhanced Counseling and Observed Therapy
International Trial of Modified Directly Observed Therapy Versus Self-Administered Therapy for Participants With First Virologic Failure on a Non-Nucleoside Reverse Transcriptase Inhibitor-Containing Antiretroviral Regimen
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Effect of directly observed therapy for highly active antiretroviral therapy on virologic, immunologic, and adherence outcomes: a meta-analysis and systematic review.Journal of acquired immune deficiency syndromes (1999) · 2010Pooled it
- Trial
- Trial
- A randomized controlled trial examining the efficacy of motivational counseling with observed therapy for antiretroviral therapy adherence.AIDS and behavior · 2013Trial
- Cost of behavioral interventions utilizing electronic drug monitoring for antiretroviral therapy adherence.Journal of acquired immune deficiency syndromes (1999) · 2013Trial
- Study design and participant characteristics of a randomized controlled trial of directly administered antiretroviral therapy in opioid treatment programs.BMC infectious diseases · 2011Trial
- Directly observed antiretroviral therapy improves adherence and viral load in drug users attending methadone maintenance clinics: a randomized controlled trial.Drug and alcohol dependence · 2011Trial
- A qualitative examination of the indirect effects of modified directly observed therapy on health behaviors other than adherence.AIDS patient care and STDs · 2008Trial
- Dispensation of antiretroviral therapy and methadone maintenance therapy at the same facility in a low-barrier setting linked to optimal adherence to HIV treatment.HIV medicine · 2019Observational
- Examining the Acceptability of mHealth Technology in HIV Prevention Among High-Risk Drug Users in Treatment.AIDS and behavior · 2017Article
- Evaluating an enhanced adherence intervention among HIV positive adolescents failing atazanavir/ritonavir-based second line antiretroviral treatment at a public health clinic.Journal of AIDS and HIV research (Online) · 2017Article
- The role of prospective memory in medication adherence: a review of an emerging literature.Journal of behavioral medicine · 2012Review
- Matching social support to individual needs: a community-based intervention to improve HIV treatment adherence in a resource-poor setting.AIDS and behavior · 2011Article
- Peer knowledge and roles in supporting access to care and treatment.Journal of community health · 2010Article
- Development of a directly observed therapy adherence intervention for adolescents with human immunodeficiency virus-1: application of focus group methodology to inform design, feasibility, and acceptability.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2009Article
- Strategies for promoting adherence to antiretroviral therapy: a review of the literature.Current infectious disease reports · 2008Article
- Adherence to biomedical HIV prevention methods: considerations drawn from HIV treatment adherence research.Current HIV/AIDS reports · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Modified directly observed therapy (mDOT), in which a portion of total doses of a medication regime is ingested under supervision, has demonstrated efficacy as an intervention to assist patients in maintaining adherence to complicated antiretroviral therapy (ART). Although findings are favorable, existing efficacy studies fail to provide sufficient detail to guide others who wish to implement mDOT interventions. The aim of this article is to provide a primer for practitioners and researchers who wish to implement mDOT interventions. Drawing on the experience of 10 federally funded research projects, we provide guidance on critical questions for program implementation, including: who should be targeted, length/duration/content/location/tapering of sessions, staffing, incentives, and approaches to data collection. In addition, guidance on staff training and minimum requirements for mDOT interventions is offered along with real-world examples of mDOT interventions. mDOT is feasible and easily adapted to many settings and target populations. Interventions should match the specific needs of the target population and setting and be flexible in terms of design and delivery. mDOT should be considered among the spectrum of adherence interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.