ArticlePlant cell reports2007
Characterization of tryptamine 5-hydroxylase and serotonin synthesis in rice plants.
Article in Plant cell reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Amelioration of cadmium toxicity in Vicia faba via modulation of caffeic acid O-methyltransferase gene expression by biochar and nanobiochar.Scientific reports · 2026Article
- OsMYB306-OsRAV11 Regulates Resistance of Rice to Striped Stem Borer by Modulating Serotonin Biosynthesis.Plant biotechnology journal · 2026Article
- A multi-omics approach reveals that the plant-parasitic nematodeParasitology · 2026Article
- Engineering hormonal crosstalk to enhance serotonin/melatonin levels in rice.Nature communications · 2025Article
- The potential of melatonin in the mitigation of adverse effects of salt stress in basil (Ocimum basilicum L.) plants.BMC plant biology · 2025Article
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- On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (Plants (Basel, Switzerland) · 2025Article
- Integrative transcriptome and metabolome evaluation of melanin biosynthesis inForestry research · 2025Article
- Views and perspectives on the indoleamines serotonin and melatonin in plants: past, present and future.Plant signaling & behavior · 2024Review
- The monoaminergic system is a bilaterian innovation.Nature communications · 2023Article
- Characterizing serotonin biosynthesis in Setaria viridis leaves and its effect on aphids.Plant molecular biology · 2022Article
- Enzyme Promiscuity in Serotonin Biosynthesis, From Bacteria to Plants and Humans.Frontiers in microbiology · 2022Review
- Ectopic overexpression of mulberryFrontiers in plant science · 2022Article
- Indolamine accumulation andFrontiers in plant science · 2022Article
- Metabolome Profiling of Heat Priming Effects, Senescence, and Acclimation of Bread Wheat Induced by High Temperatures at Different Growth Stages.International journal of molecular sciences · 2021Article
- Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals-An Overview.International journal of molecular sciences · 2021Review
- Metabolite profiling and transcriptome analyses reveal novel regulatory mechanisms of melatonin biosynthesis in hickory.Horticulture research · 2021Article
- Key Genes in the Melatonin Biosynthesis Pathway with Circadian Rhythm Are Associated with Various Abiotic Stresses.Plants (Basel, Switzerland) · 2021Article
- A Systematic Review of Melatonin in Plants: An Example of Evolution of Literature.Frontiers in plant science · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonin is a well-known pineal hormone that in mammals plays a key role in mood. In plants, serotonin is implicated in several physiological roles such as flowering, morphogenesis, and adaptation to environmental changes. However, its biosynthetic enzyme in plants has not been characterized. Therefore, we measured the serotonin content and enzyme activity responsible for serotonin biosynthesis in rice seedlings. Tryptamine 5-hydroxylase (T5H), which converts tryptamine into serotonin, was found as a soluble enzyme that had maximal activity in the roots. The maximal activity of T5H was closely associated with the enriched synthesis of serotonin in roots. Tetrahydropterine-dependent T5H activity was inhibited by tyramine, tryptophan, 5-OH-tryptophan, and octopamine, but remained unaltered by dopamine in vitro. The tissues of rice seedlings grown in the presence of tryptamine exhibited a dose-dependent increase in serotonin in parallel with enhanced T5H enzyme activity. However, no significant increase in serotonin was observed in rice tissues grown in the presence of tryptophan, suggesting that tryptamine is a bottleneck intermediate substrate for serotonin synthesis.
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