Duality of p27Kip1 function in tumorigenesis.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

26 citing papers in PubMed, 51 citations in OpenAlex.

1. p27 transcriptionally coregulates cJun to drive programs of tumor progression.Proceedings of the National Academy of Sciences of the United States of America · 2019
   Article
2. Akt/p27International journal of endocrinology · 2018
   Article
3. The Cell Cycle Inhibitors p21Neoplasia (New York, N.Y.) · 2017
   Article
4. Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D.Genes & development · 2016
   Article
5. Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescence.Oncotarget · 2015
   Article
6. Functional characterization of a CDKN1B mutation in a Sardinian kindred with multiple endocrine neoplasia type 4 (MEN4).Endocrine connections · 2015
   Article
7. Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.Gut · 2014
   Article
8. miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27(kip1).Oncogene · 2014
   Article
9. Interruption of nuclear localization of ATBF1 during the histopathologic progression of head and neck squamous cell carcinoma.Head & neck · 2013
   Article
10. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.International journal of oncology · 2013
    Article
11. Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex.Oncogene · 2013
    Article
12. p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes.Oncogene · 2012
    Article
13. The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment.Developmental cell · 2012
    Article
14. XMRV accelerates cellular proliferation, transformational activity, and invasiveness of prostate cancer cells by downregulating p27(Kip1).The Prostate · 2012
    Article
15. Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility.The Journal of biological chemistry · 2011
    Article
16. cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.Toxicological sciences : an official journal of the Society of Toxicology · 2011
    Article
17. Epithelial-myoepithelial tumour of the lung: a case report referring to its molecular histogenesis.Diagnostic pathology · 2011
    Article
18. Stem cells and cell therapies in lung biology and lung diseases.Proceedings of the American Thoracic Society · 2011
    Article
19. Stem cells and cell therapy approaches in lung biology and diseases.Translational research : the journal of laboratory and clinical medicine · 2010
    Review
20. Loss of nuclear p27(kip1) and α-dystroglycan is a frequent event and is a strong predictor of poor outcome in renal cell carcinoma.Cancer science · 2010
    Article

Corrections and comments

• Comment on
  Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.2007

Authors and funding

3 authors at 2 institutions in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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