ArticleCancer research2007
Small interfering RNA directed reversal of urokinase plasminogen activator demethylation inhibits prostate tumor growth and metastasis.
Article in Cancer research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer.Carcinogenesis · 2020Article
- Retraction: Small Interfering RNA-Directed Reversal of Urokinase Plasminogen Activator Demethylation Inhibits Prostate Tumor Growth and Metastasis.Cancer research · 2018Article
- Study of the Role of siRNA Mediated Promoter Methylation in DNMT3B Knockdown and Alteration of Promoter Methylation of CDH1, GSTP1 Genes in MDA-MB -453 Cell Line.Iranian journal of pharmaceutical research : IJPR · 2017Article
- Transcriptional gene silencing in humans.Nucleic acids research · 2016Article
- Effect of urokinase-type plasminogen activator system in gastric cancer with peritoneal metastasis.Oncology letters · 2016Article
- The varied roles of nuclear argonaute-small RNA complexes and avenues for therapy.Molecular therapy. Nucleic acids · 2014Review
- Radiation-induced hypomethylation triggers urokinase plasminogen activator transcription in meningioma cells.Neoplasia (New York, N.Y.) · 2013Article
- TGF-β1 alters microRNA profile in human gastric cancer cells.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- Multimodality imaging of RNA interference.Current medicinal chemistry · 2013Review
- Promoter-associated RNAs and promoter-targeted RNAs.Cellular and molecular life sciences : CMLS · 2012Review
- Article
- Cell surface remodeling by plasmin: a new function for an old enzyme.Journal of biomedicine & biotechnology · 2012Review
- Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells.Neoplasia (New York, N.Y.) · 2011Article
- Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters.Nucleic acids research · 2011Article
- Minireview: Switching on progesterone receptor expression with duplex RNA.Molecular endocrinology (Baltimore, Md.) · 2010Review
- Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by host-derived urokinase-type plasminogen activator.Journal of cellular and molecular medicine · 2010Article
- Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter.Nucleic acids research · 2010Article
- Epigenetic upregulation of urokinase plasminogen activator promotes the tropism of mesenchymal stem cells for tumor cells.Molecular cancer research : MCR · 2010Article
- Controlling transcription with noncoding RNAs in mammalian cells.BioTechniques · 2010Review
- Radiation-inducible silencing of uPA and uPAR in vitro and in vivo in meningioma.International journal of oncology · 2010Article
Corrections and comments
- Retraction · 2018-06-14Civil Proceedings · Duplication of/in Image · Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution · Investigation by Journal/Publisher · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Objections by Author(s) · · Jasti S Rao has institutional finding of misconduct;
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies have shown that small interfering RNA (siRNA) silences genes at the transcriptional level in human cells. However, the therapeutic potential of siRNA-mediated transcriptional gene silencing remains unclear. Here, we show that siRNA targeted to the urokinase plasminogen activator (uPA) promoter induced epigenetic transcriptional silencing in human prostate cancer cells. This silencing resulted in a dramatic reduction of tumor cell invasion and angiogenesis in vitro. Furthermore, the results from a bioluminescence tumor/metastasis model showed that the silencing of uPA significantly inhibits prostate tumor growth and the incidence of lung metastasis. Our findings represent a potentially powerful new approach to not only epigenetic silencing of metastasis or growth-promoting genes as a cancer therapy, but also as a means to shed light on how aberrant de novo methylation during cancer progression might be targeted to specific sequences.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.