ArticleBlood2007
Signaling through CD43 regulates CD4 T-cell trafficking.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Lung NR3C1Communications biology · 2025Article
- Buprenorphine's Effect on the Human Immune System and Inflammation.Clinical and translational science · 2025Review
- Temporal evolution and inter-patient heterogeneity in primary and recurrent head and neck squamous cell carcinoma.BJC reports · 2024Article
- The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation.The Journal of biological chemistry · 2024Article
- Mechanism of isorhynchophylline in lipopolysaccharide-induced acute lung injury based on proteomic technology.Frontiers in pharmacology · 2024Article
- Transplantation elicits a clonally diverse CD8Cell reports · 2023Article
- Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Sialomucin CD43 Plays a Deleterious Role in the Development of Experimental Heart Failure Induced by Pressure Overload by Modulating Cardiac Inflammation and Fibrosis.Frontiers in physiology · 2021Article
- CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection.Scientific reports · 2019Article
- E-Selectin Ligands in the Human Mononuclear Phagocyte System: Implications for Infection, Inflammation, and Immunotherapy.Frontiers in immunology · 2017Review
- An alternative mode of CD43 signal transduction activates pro-survival pathways of T lymphocytes.Immunology · 2017Article
- Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Common polymorphisms in the CD43 gene region are associated with tuberculosis disease and mortality.American journal of respiratory cell and molecular biology · 2015Article
- CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
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- Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells.PLoS pathogens · 2012Article
- CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation.Molecular biology of the cell · 2011Article
- Age-related defects in the cytoskeleton signaling pathways of CD4 T cells.Ageing research reviews · 2011Review
- The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase.The Journal of biological chemistry · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The mucin-like protein CD43 is excluded from the immune synapse, and regulates T-cell proliferation as well as T-cell migration. While the CD43 cytoplasmic domain is necessary for regulation of T-cell activation and proliferation, the mechanism via which CD43 regulates trafficking is not well defined. To investigate whether CD43 phosphorylation regulates its function in T cells, we used tandem mass spectrometry and identified Ser76 in murine CD43 as a previously unidentified site of basal phosphorylation. Interestingly, mutation of this single serine to alanine greatly diminishes T-cell trafficking to the lymph node, while CD43 exclusion and CD43-mediated regulation of T-cell proliferation remain intact. Furthermore, the CD43 extracellular domain was also required for T-cell trafficking, providing a hitherto unknown function for the extracellular domain, and suggesting that the extracellular domain may be required to transduce signals via the cytoplasmic domain. These data reveal a novel mechanism by which CD43 regulates T-cell function, and suggest that CD43 functions as a signaling molecule, sensing extracellular cues and transducing intracellular signals that modulate T-cell function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.