Evidence map›Paper›PMID 17638613›Full record

ReviewThe Lancet. Neurology2007

Spastic movement disorder: impaired reflex function and altered muscle mechanics.

Volker Dietz, Thomas Sinkjaer

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in The Lancet. Neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 209 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 8 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06564714 phase4not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury to Promote Long-term Neurofunctional Recovery: a Randomized Clinical Trial

TypeinterventionalSponsorCentre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de MontrealRan2024 to 2029Enrolled55ConditionsTraumatic Spinal Cord InjuryArmsEarly baclofen Intervention, Usual routine care
NCT06898242 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Early Myofascial Manual Treatment in Subjects With Spasticity Following Acquired Brain Injury

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2025 to 2026Enrolled24ConditionsBrain Injury, Brain Injury, Vascular, Brain Injuries, TraumaticArmsManual myofascial treatment direct to upper and lower limb, Rehabilitative treatment following rehabilitation project
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 8 syntheses or guidelines pooled it, 565 citations in OpenAlex.

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  4. Brain Plasticity in Patients with Spinal Cord Injuries: A Systematic Review.International journal of molecular sciences · 2024
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  15. Ankle Mechanical Impedance During Waling in Chronic Stroke: Preliminary Results.IEEE ... International Conference on Rehabilitation Robotics : [proceedings] · 2019
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  18. Robot Training With Vector Fields Based on Stroke Survivors' Individual Movement Statistics.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2018
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149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Volker DietzSpinal Cord Injury Centre, University of Zurich, Switzerland. volker.dietz@balgrist.ch
Thomas Sinkjaer
Aalborg University · DKUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In clinical practice, signs of exaggerated tendon tap reflexes associated with muscle hypertonia are generally thought to be responsible for spastic movement disorders. Most antispastic treatments are, therefore, directed at the reduction of reflex activity. In recent years, however, researchers have noticed a discrepancy between spasticity as measured in the clinic and functional spastic movement disorders, which is primarily due to the different roles of reflexes in passive and active states, respectively. We now know that central motor lesions are associated with loss of supraspinal drive and defective use of afferent input with impaired behaviour of short-latency and long-latency reflexes. These changes lead to paresis and maladaptation of the movement pattern. Secondary changes in mechanical muscle fibre, collagen tissue, and tendon properties (eg, loss of sarcomeres, subclinical contractures) result in spastic muscle tone, which in part compensates for paresis and allows functional movements on a simpler level of organisation. Antispastic drugs can accentuate paresis and therefore should be applied with caution in mobile patients.

Indexed as

Central Nervous SystemHumansMovement DisordersMuscle SpasticityReflexWalking

Identifiers

PMID17638613
OpenAlexW2102924247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.