ArticleGene expression patterns : GEP2007
Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle.
Article in Gene expression patterns : GEP, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 72 citations in OpenAlex.
- Transcriptomic and Metabolomic Insights into Growth Performance of a Novel Allotriploid Fish Derived fromAnimals : an open access journal from MDPI · 2026Article
- Trunk Muscle Differentiation and Growth in Vertebrates.Results and problems in cell differentiation · 2026Review
- Characterization of Myf6 and association with growth traits in swimming crab (Portunus trituberculatus).BMC genomics · 2024Article
- Molecular Characterization, Expression Analysis, and CRISPR/Cas9 Mediated Gene Disruption of Myogenic Regulatory Factor 4 (MRF4) in Nile Tilapia.Current issues in molecular biology · 2024Article
- Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation.Developmental biology · 2023Article
- The Presence of TwoJournal of developmental biology · 2023Article
- Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology.Marine biotechnology (New York, N.Y.) · 2023Review
- Potential Mechanism and Effects of Different Selenium Sources and Different Effective Microorganism Supplementation Levels on Growth Performance, Meat Quality, and Muscle Fiber Characteristics of Three-Yellow Chickens.Frontiers in nutrition · 2022Article
- Changes of Gene Expression Patterns of Muscle Pathophysiology-Related Transcription Factors During Denervated Muscle Atrophy.Frontiers in physiology · 2022Article
- Article
- Myogenic regulatory factors are key players in determining muscle mass and meat quality in Jeju native and Berkshire pigs.Veterinary medicine and science · 2021Article
- Article
- Development and patterning of rib primordia are dependent on associated musculature.Developmental biology · 2020Article
- Skeletal Muscle and the Effects of Ammonia Toxicity in Fish, Mammalian, and Avian Species: A Comparative Review Based on Molecular Research.International journal of molecular sciences · 2020Review
- Maternal Larp6 controls oocyte development, chorion formation and elevation.Development (Cambridge, England) · 2020Article
- Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro.Skeletal muscle · 2017Article
- Comparative myogenesis in teleosts and mammals.Cellular and molecular life sciences : CMLS · 2014Review
- MicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1.Journal of cell science · 2014Article
- Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish.Developmental biology · 2011Article
- Cdkn1c drives muscle differentiation through a positive feedback loop with Myod.Developmental biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Mrf4 (Myf6) is a member of the basic helix-loop-helix (bHLH) myogenic regulatory transcription factor (MRF) family, which also contains Myod, Myf5 and myogenin. Mrf4 is implicated in commitment of amniote cells to skeletal myogenesis and is also abundantly expressed in many adult muscle fibres. The specific role of Mrf4 is unclear both because mrf4 null mice are viable, suggesting redundancy with other MRFs, and because of genetic interactions at the complex mrf4/myf5 locus. We report the cloning and expression of an mrf4 gene from zebrafish, Danio rerio, which shows conservation of linkage to myf5. Mrf4 mRNA accumulates in a subset of terminally differentiated muscle fibres in parallel with myosin protein in the trunk and fin. Although most, possibly all, trunk muscle expresses mrf4, the level of mRNA is dynamically regulated. No expression is detected in muscle precursor cell populations prior to myosin accumulation. Moreover, mrf4 expression is not detected in head muscles, at least at early stages. As fish mature, mrf4 expression is pronounced in the region of slow muscle fibres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.