ArticleDevelopmental neurobiology2007
Axon extension in the fast and slow lanes: substratum-dependent engagement of myosin II functions.
Article in Developmental neurobiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration.Molecular neurobiology · 2024Review
- Establishing neuronal polarity: microtubule regulation during neurite initiation.Oxford open neuroscience · 2022Review
- SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics.Frontiers in molecular neuroscience · 2022Article
- Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids.eLife · 2021Article
- The bioenergetics of neuronal morphogenesis and regeneration: Frontiers beyond the mitochondrion.Developmental neurobiology · 2020Review
- Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?Frontiers in cellular neuroscience · 2020Article
- The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology.Neural development · 2019Review
- Modeling the Axon as an Active Partner with the Growth Cone in Axonal Elongation.Biophysical journal · 2018Article
- An Integrated Cytoskeletal Model of Neurite Outgrowth.Frontiers in cellular neuroscience · 2018Review
- Neurite elongation is highly correlated with bulk forward translocation of microtubules.Scientific reports · 2017Article
- Axon tension regulates fasciculation/defasciculation through the control of axon shaft zippering.eLife · 2017Article
- Drebrin coordinates the actin and microtubule cytoskeleton during the initiation of axon collateral branches.Developmental neurobiology · 2016Article
- Actin filament-microtubule interactions in axon initiation and branching.Brain research bulletin · 2016Review
- Nerve growth factor stimulates axon outgrowth through negative regulation of growth cone actomyosin restraint of microtubule advance.Molecular biology of the cell · 2016Article
- Nerve growth factor promotes reorganization of the axonal microtubule array at sites of axon collateral branching.Developmental neurobiology · 2015Article
- The dynein inhibitor Ciliobrevin D inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches.Developmental neurobiology · 2015Article
- Cytoskeletal and signaling mechanisms of neurite formation.Cell and tissue research · 2015Review
- Quantifying mechanical force in axonal growth and guidance.Frontiers in cellular neuroscience · 2015Review
- Article
- Mitochondria coordinate sites of axon branching through localized intra-axonal protein synthesis.Cell reports · 2013Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Axon extension involves the coordinated regulation of the neuronal cytoskeleton. Actin filaments drive protrusion of filopodia and lamellipodia while microtubules invade the growth cone, thereby providing structural support for the nascent axon. Furthermore, in order for axons to extend the growth cone must attach to the substratum. Previous work indicates that myosin II activity inhibits the advance of microtubules into the periphery of growth cones, and myosin II has also been implicated in mediating integrin-dependent cell attachment. However, it is not clear how the functions of myosin II in regulating substratum attachment and microtubule advance are integrated during axon extension. We report that inhibition of myosin II function decreases the rate of axon extension on laminin, but surprisingly promotes extension rate on polylysine. The differential effects of myosin II inhibition on axon extension rate are attributable to myosin II having the primary function of mediating substratum attachment on laminin, but not on polylysine. Conversely, on polylysine the primary function of myosin II is to inhibit microtubule advance into growth cones. Thus, the substratum determines the role of myosin II in axon extension by controlling the functions of myosin II that contribute to extension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.