ArticleJournal of muscle research and cell motility2007
Smooth muscle persists in the muscularis externa of developing and adult mouse esophagus.
Article in Journal of muscle research and cell motility, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- A mathematical model of human oesophageal motility function.Royal Society open science · 2025Article
- Immunohistochemical characterization of interstitial cells and their spatial relationship to motor neurons within the mouse esophagus.Cell and tissue research · 2025Article
- Immunohistochemical characterization of interstitial cells and their relationship to motor neurons within the mouse esophagus.Research square · 2024Article
- Butyrylcholinesterase distribution in the mouse gastrointestinal tract: An immunohistochemical study.Journal of anatomy · 2023Article
- Abnormalities in esophageal smooth muscle induced by mutations in collagen XIX.Histochemistry and cell biology · 2022Article
- Article
- Bi-layer silk fibroin grafts support functional tissue regeneration in a porcine model of onlay esophagoplasty.Journal of tissue engineering and regenerative medicine · 2018Article
- Enteric co-innervation of striated muscle in the esophagus: still enigmatic?Histochemistry and cell biology · 2016Review
- Embracing change: striated-for-smooth muscle replacement in esophagus development.Skeletal muscle · 2016Review
- PAX7 is required for patterning the esophageal musculature.Skeletal muscle · 2015Article
- Smooth muscle fascicular reorientation is required for esophageal morphogenesis and dependent on Cdo.The Journal of cell biology · 2013Article
- Molecular aspects of esophageal development.Annals of the New York Academy of Sciences · 2011Article
- The expression of nestin delineates skeletal muscle differentiation in the developing rat esophagus.Journal of anatomy · 2011Article
- Striated myogenesis and peristalsis in the fetal murine esophagus occur without cell migration or interstitial cells of Cajal.Cells, tissues, organs · 2009Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Following initial patterning as differentiated smooth muscle (SM) cells, the muscularis externa of the murine esophagus is replaced by skeletal muscle, but the mechanism underlying this process is controversial. The hypothesis that committed SM cells transdifferentiate into striated muscle is not consistent with fate mapping studies. Similarly, apoptosis does not fully explain the process. Using immunohistochemical techniques and transgenic mice that express eGFP and Cre-recombinase exclusively in SM, we have identified a population of remnant SM cells that persist throughout the developing and mature murine esophagus. These cells display an atypical phenotype, are not associated with microvasculature, but are often apposed to cKit positive, interstitial cells of Cajal. The absolute length of the SM component of the developing esophagus remains constant during a period when total esophageal length increases 4-fold, resulting in a small maintained distal segment of smooth muscle. Esophageal SM cells fail to express myogenin during development, and striated muscle cell precursors expressing myogenin fail to express specific SM cell markers, indicating that they did not transdifferentiate from SM cells. Moreover, smooth muscle-specific myogenin inactivation has no effect on esophageal skeletal myogenesis. Taken together, our results provide an alternative hypothesis regarding the fate of SM cells in the developing murine esophagus, which does not invoke apoptosis or transdifferentiation.
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