ArticlePediatric nephrology (Berlin, Germany)2007
Renal hemodynamic changes and renal functional reserve in children with type I diabetes mellitus.
Article in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- A systematic review of glomerular hyperfiltration assessment and definition in the medical literature.Clinical journal of the American Society of Nephrology : CJASN · 2015Pooled it
- Recurrent Antibiotic-Treated Pyelonephritis Depletes Renal Functional Reserve Despite Preserved Basal GFR in a Reflux-Prone Mouse Model.Journal of the American Society of Nephrology : JASN · 2026Article
- Preoperative renal functional reserve as a predictor of acute kidney injury in young adults with congenital heart disease.Scientific reports · 2025Article
- Intermittent protein restriction before but not after the onset of diabetic kidney disease attenuates disease progression in mice.Frontiers in nutrition · 2024Article
- Glomerular hyperfiltration.Nature reviews. Nephrology · 2022Review
- The roles of protein load test in quantitatively evaluating renal function after severe unilateral ureteral obstruction in adult rabbits.Quantitative imaging in medicine and surgery · 2021Article
- The Role of Renal Functional Reserve in Predicting Acute Kidney Injury.Critical care clinics · 2021Review
- Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: Detecting subclinical kidney injury.Congenital heart disease · 2019Article
- Rethinking CKD Evaluation: Should We Be Quantifying Basal or Stimulated GFR to Maximize Precision and Sensitivity?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Review
- The aging kidney and the nephrotoxic effects of mercury.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Simultaneous onset of steroid resistant nephrotic syndrome and IDDM in two young children.BMJ case reports · 2010Article
- Oxidant/antioxidant status and hyperfiltration in young patients with type 1 diabetes mellitus.Pediatric nephrology (Berlin, Germany) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased glomerular filtration rate (GFR) has been implicated in the development of diabetic nephropathy. Large normal interindividual variations of GFR hamper the diagnosis of renal hemodynamic alterations. We examined renal functional reserve (RFR) in children with type 1 diabetes mellitus to assess whether hyperfiltration occurs. The renal hemodynamic response following dopamine infusion was examined in 51 normoalbuminuric diabetic children (7.7 +/- 3.6 years) with a mean duration of diabetes of 6.2 years and compared them with 34 controls. Mean baseline GFR in diabetic children did not differ from the control population (130.7 +/- 22.9 vs. 124.8 +/- 25 ml/min per 1.73 m(2)), whereas renal plasma flow was significantly lower (463.7 +/- 103.9 vs. 587.2 +/- 105 ml/min per 1.73 m(2), p < 0.001), and filtration fraction was increased (29 +/- 8 vs. 21 +/- 2%, p < 0.001), compared with controls. The mean RFR was lower (p < 0.001) than in control subjects (-0.77 +/- 23 vs. 21 +/- 8 ml/min per 1.73 m(2)). This study documents an increased filtration fraction and reduced or absent RFR in children with type 1 diabetes mellitus in the stage before apparent nephropathy. GFR values were within normal range. Although the reduced RFR and increased filtration fraction indicate the presence of hemodynamic changes, their relevance to the development of hyperfiltration and subsequent diabetic nephropathy remains unknown.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.