ArticleMolecular genetics and genomics : MGG2007
Post-integration behavior of a Minos transposon in the malaria mosquito Anopheles stephensi.
Article in Molecular genetics and genomics : MGG, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Molecular tools to create new strains for mosquito sexing and vector control.Parasites & vectors · 2018Review
- Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?International journal of environmental research and public health · 2017Review
- nanos-Driven expression of piggyBac transposase induces mobilization of a synthetic autonomous transposon in the malaria vector mosquito, Anopheles stephensi.Insect biochemistry and molecular biology · 2017Article
- Functional characterization of the activeMobile DNA · 2017Article
- PiggyBac transposon-based polyadenylation-signal trap for genome-wide mutagenesis in mice.Scientific reports · 2016Article
- Tools for Anopheles gambiae Transgenesis.G3 (Bethesda, Md.) · 2015Article
- Gal4-based enhancer-trapping in the malaria mosquito Anopheles stephensi.G3 (Bethesda, Md.) · 2012Article
- ATon, abundant novel nonautonomous mobile genetic elements in yellow fever mosquito (Aedes aegypti).BMC genomics · 2012Article
- piggyBac transposon remobilization and enhancer detection in Anopheles mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mobility properties of the Hermes transposable element in transgenic lines of Aedes aegypti.Genetica · 2011Article
- A new powerful method for site-specific transgene stabilization based on chromosomal double-strand break repair.PloS one · 2011Article
- Review
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6 authors at 2 institutions in 2 countries.
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Abstract
Transposable elements represent important tools to perform functional studies in insects. In Drosophila melanogaster, the remobilization properties of transposable elements have been utilized for enhancer-trapping and insertional mutagenesis experiments, which have considerably helped in the functional characterization of the fruitfly genome. In Anopheles mosquitoes, the sole vectors of human malaria, as well as in other mosquito vectors of disease, the use of transposons has also been advocated to achieve the spread of anti-parasitic genes throughout field populations. Here we report on the post-integration behavior of the Minos transposon in both the germ-line and somatic tissues of Anopheles mosquitoes. Transgenic An. stephensi lines developed using the piggyBac transposon and expressing the Minos transposase were tested for their ability to remobilize an X-linked Minos element. Germ-line remobilization events were not detected, while somatic excisions and transpositions were consistently recovered. The analysis of these events showed that Minos activity in Anopheles cells is characterized by unconventional functionality of the transposon. In the two cases analyzed, re-integration of the transposon occurred onto the same X chromosome, suggesting a tendency for local hopping of Minos in the mosquito genome. This is the first report of the post-integration behavior of a transposable element in a human malaria vector.
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