ReviewMedical microbiology and immunology2008
Heat shock proteins: linking danger and pathogen recognition.
Review in Medical microbiology and immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 141 citations in OpenAlex.
- Identification and characterization of the HSP gene family in the Chinese giant salamander: Expression patterns under combined environmental stress.BMC genomics · 2026Article
- Heat stress promotes the accumulation of tomato yellow leaf curl virus in its insect vector by activating heat shock factor.Crop health · 2024Article
- Article
- Cu-doped TiOJournal of nanobiotechnology · 2023Article
- Mycobacterial Heat Shock Proteins in Sarcoidosis and Tuberculosis.International journal of molecular sciences · 2023Review
- Liver Proteome Alterations in Red Deer (Pathogens (Basel, Switzerland) · 2022Article
- Review
- Article
- HSP70-Homolog DnaK ofInternational journal of molecular sciences · 2020Article
- Cystic Fibrosis Defective Response to Infection Involves Autophagy and Lipid Metabolism.Cells · 2020Article
- Circulating heat shock protein 27 as a novel marker of subclinical atherosclerosis in type 2 diabetes: a cross-sectional community-based study.BMC cardiovascular disorders · 2020Article
- Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion.International journal of molecular sciences · 2019Review
- The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide.International journal of molecular sciences · 2019Article
- CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.Journal of pain research · 2019Article
- Promising Plant-Derived Adjuvants in the Development of Coccidial Vaccines.Frontiers in veterinary science · 2019Review
- An overview of cytokines and heat shock response in polytraumatized patients.Cell stress & chaperones · 2018Review
- Safety of Therapeutic Fever Induction in Cancer Patients Using Approved PAMP Drugs.Translational oncology · 2018Article
- Radiofrequency assisted pancreaticoduodenectomy for palliative surgical resection of locally advanced pancreatic adenocarcinoma.Oncotarget · 2018Article
- Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis.Cell death and differentiation · 2017Article
- Activation of TRIF-dependent and independent immune responses by neisserial heat shock protein complex vaccines.Human vaccines & immunotherapeutics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides their central function in protein folding and transport within the cell, heat shock proteins (HSP) have been shown to modulate innate and adaptive immune response: (1) HSP mediate uptake and MHC presentation of HSP-associated peptides by antigen-presenting cells (APC). (2) HSP function as endogenous danger signals indicating cell stress and tissue damage to the immune system. (3) HSP bind pathogen-associated molecular pattern (PAMP) molecules and modulate PAMP-induced Toll-like receptor (TLR) signaling. Thus, HSP contribute to both, recognition of "danger" defined as uncontrolled tissue destruction and recognition of dangerous "nonself". In this review these different aspects of immune stimulation by HSP will be discussed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.