ArticlePflugers Archiv : European journal of physiology2007
Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding.
Article in Pflugers Archiv : European journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Observational
- Role of fatty acid transport protein 4 in metabolic tissues: insights into obesity and fatty liver disease.Bioscience reports · 2022Review
- Chylous ascites with lymphatic leakage localization: technical aspects and clinical applications.BMC surgery · 2022Article
- Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns.Nutrients · 2021Article
- Safety, health improvement and well-being during a 4 to 21-day fasting period in an observational study including 1422 subjects.PloS one · 2019Observational
- Changes in human gut microbiota composition are linked to the energy metabolic switch during 10 d of Buchinger fasting.Journal of nutritional science · 2019Article
- Maintenance of Distal Intestinal Structure in the Face of Prolonged Fasting: A Comparative Examination of Species From Five Vertebrate Classes.Anatomical record (Hoboken, N.J. : 2007) · 2017Article
- Di- and tripeptide transport in vertebrates: the contribution of teleost fish models.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Regulation profile of the intestinal peptide transporter 1 (PepT1).Drug design, development and therapy · 2017Review
- Peptide-based enteral formula improves tolerance and clinical outcomes in abdominal surgery patients relative to a whole protein enteral formula.World journal of gastrointestinal surgery · 2016Article
- Histological aspects of the small intestine under variable feed restriction: The effects of short and intense restriction on a growing rabbit model.Experimental and therapeutic medicine · 2014Article
- Cloning and molecular characterization of cationic amino acid transporter y⁺LAT1 in grass carp (Ctenopharyngodon idellus).Fish physiology and biochemistry · 2014Article
- The effect of fasting and refeeding on mRNA expression of PepT1 and gastrointestinal hormones regulating digestion and food intake in zebrafish (Danio rerio).Fish physiology and biochemistry · 2012Article
- Peptide transport and animal growth: the fish paradigm.Biology letters · 2011Article
- Mechanisms of chylomicron uptake into lacteals.Annals of the New York Academy of Sciences · 2010Review
- Lymphatic lipid transport: sewer or subway?Trends in endocrinology and metabolism: TEM · 2010Review
- A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics.Biotechnology and bioengineering · 2009Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal villus atrophy through prolonged fasting was studied according to two different metabolic phases reached by fasting animals and characterized by (a) the mobilization of fat stores as body fuel and (b) an increase in protein catabolism for energy expenditure. The mechanisms involved in the rapid jejunal restoration after refeeding were also determined. Mucosal structural atrophy during fasting proved to worsen over the two phases due mainly to the retraction of the lacteals in the lamina propria, as observed through the immunolocalization of aquaporin 1 in the endothelial cells of the lymphatic vessels and the detachment of the basal membrane of the epithelial lining at the tip of the villi. Microvilli surface area is preserved through fasting, and apical PepT1 expression increases during both metabolic fasting phases. Refeeding after both fasting phases induces an increase in FATP4 accompanied by a rapid lipid uptake by the enterocytes at the tip of the villi and a rapid extension of the lamina propria due to inflated lymphatic vessels. These mechanisms were more prevalent in animals refed after the phase III fast and could be considered as the major processes allowing complete morphological restoration of the jejunum within only 3 days after refeeding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.