Evidence map›Paper›PMID 17637967›Full record

ArticleOrganic & biomolecular chemistry2007

Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids.

Hai Yu, Harshal A Chokhawala, Ajit Varki, Xi Chen

Open access · greenAbstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Synthesis ofFrontiers in immunology · 2019
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. General consideration on sialic acid chemistry.Methods in molecular biology (Clifton, N.J.) · 2012
    Review
  12. Article
  13. Article
  14. Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives.Chemical communications (Cambridge, England) · 2011
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hai YuDepartment of Chemistry, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Harshal A Chokhawala
Ajit Varki
Xi Chen
University of California, Davis · USUniversity of California, San Diego · US

Funding

Studies of Naturally Occurring Structurally Modified CarbohydratesR01GM076360 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI · 2006 to 2010
$1.9M
NIGMS NIH HHS R01 GM 076360NIGMS NIH HHS R01 GM076360
6 · The paper itself

Abstract

Sialyl Tn (STn) and sialyl lactoside derivatives containing O-acetylated sialic acid residues have been chemoenzymatically synthesized using a one-pot three-enzyme system and conjugated to biotinylated human serum albumin (HSA) using an adipic acid para-nitrophenyl ester coupling reagent. This approach provides an efficient and general protocol for preparing carbohydrate-protein conjugates containing base-sensitive groups.

Indexed as

AcetylationBiotinGlycosidesHumansMolecular StructureSerum AlbuminSialic AcidsSialyltransferasesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBiotinGlycosidesSerum AlbuminSialic AcidsSialyltransferases

Identifiers

PMID17637967
PMCPMC2769491
OpenAlexW2089856994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.