ArticleEnvironmental health perspectives2007
Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 68 citations in OpenAlex.
- Cutaneous manifestations and treatment of arsenic toxicity: A systematic review.Skin health and disease · 2023Review
- Metals and Metallothionein Expression in Relation to Progression of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka.Diseases (Basel, Switzerland) · 2022Article
- Serum Proteomic Profiling Analysis of Rats Chronically Exposed to Arsenic.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- α-Synuclein Enhances Cadmium Uptake and Neurotoxicity via Oxidative Stress and Caspase Activated Cell Death Mechanisms in a Dopaminergic Cell Model of Parkinson's Disease.Neurotoxicity research · 2017Article
- Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure.Toxicology and applied pharmacology · 2015Article
- Metallothionein blocks oxidative DNA damage in vitro.Archives of toxicology · 2013Article
- The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels?International archives of occupational and environmental health · 2012Article
- Diurnal-and sex-related difference of metallothionein expression in mice.Journal of circadian rhythms · 2012Article
- Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: requirement for Cyp1a1.Chemico-biological interactions · 2011Article
- Arsenic- and cadmium-induced toxicogenomic response in mouse embryos undergoing neurulation.Toxicology and applied pharmacology · 2011Article
- Article
- Embryonic toxicokinetic and dynamic differences underlying strain sensitivity to cadmium during neurulation.Reproductive toxicology (Elmsford, N.Y.) · 2010Article
- Arsenic-specific stem cell selection during malignant transformation.Journal of the National Cancer Institute · 2010Article
- Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- Metallothionein protection of cadmium toxicity.Toxicology and applied pharmacology · 2009Review
- V-PROLI/NO, a nitric oxide donor prodrug, protects liver cells from arsenic-induced toxicity.Cancer science · 2009Article
- Effect of cadmium chloride on metallothionein levels in carp.Sensors (Basel, Switzerland) · 2009Article
- The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis.Cancer letters · 2007Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBecause metallothionein (MT) is a metal-binding protein that protects against metal intoxication, it could be a biomarker for individual sensitivity to metal toxicity.
objectiveWe assessed the use of bloodborne MT transcript as a reflection of tissue MT levels and examined the potential role of MT in arsenic toxicity in an environmentally exposed human population.
methodRodents were treated with zinc or nonmetallic MT inducers for 4 days, and the blood and tissues were collected for MT transcript analysis by real-time reverse transcriptase-polymerase chain reaction and MT protein determination by the cadmium-hemoglobin assay. Blood and buccal cell samples were collected from arsenicosis patients and healthy subjects residing in Guizhou, China, and total RNA was isolated for MT transcript analysis.
resultsThere was a positive correlation between blood MT-1 and MT-2 transcripts and corresponding hepatic or renal MT transcript levels in rats and mice. Furthermore, there was a positive correlation between blood MT-1 and MT-2 transcript and tissue MT protein levels in these animals. A positive correlation also occurred between human blood MT and buccal cell MT transcript levels. MT-1A and MT-2A were the major isoform transcripts in human blood and buccal cells, and significantly lower MT levels were seen in arsenicosis patients compared with healthy subjects.
conclusionsBlood MT transcript appears to be a useful biomarker of tissue MT levels. Arsenicosis patients in Guizhou show significantly lower MT transcript levels in blood, which may have predisposed this population to arsenic intoxication.
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