SynthesisJournal of perinatology : official journal of the California Perinatal Association2007
Congenital diaphragmatic hernia: a systematic review and summary of best-evidence practice strategies.
Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Guideline
- Preliminary observations of the use of high-frequency jet ventilation as rescue therapy in infants with congenital diaphragmatic hernia.Journal of pediatric surgery · 2010Trial
- Repeated Treatments With Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia Patients: A Registry Analysis.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Association between vasoactive-inotropic score, clinical outcomes, defect size and laterality in congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Feasibility of invasive neurally-adjusted ventilatory assist in severe congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2026Observational
- Impact of fetal treatments for congenital diaphragmatic hernia on lung development.Anatomical record (Hoboken, N.J. : 2007) · 2025Review
- Omphalocele and Associated Anomalies: Exploring Pulmonary Development and Genetic Correlations-A Literature Review.Diagnostics (Basel, Switzerland) · 2025Review
- Beyond Bronchopulmonary Dysplasia: A Comprehensive Review of Chronic Lung Diseases in Neonates.Cureus · 2024Review
- Antiasthmatic prescriptions in children with and without congenital anomalies: a population-based study.BMJ open · 2023Article
- Successful extracorporeal membrane oxygenation for postoperative cardiopulmonary failure in newborns with congenital diaphragmatic hernia: case reports and literature reviews.Frontiers in pediatrics · 2023Article
- High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients.Platelets · 2022Article
- Optimal timing of surgery in infants with prenatally diagnosed isolated left-sided congenital diaphragmatic hernia: a multicenter, cohort study in Japan.Surgery today · 2021Article
- Congenital diaphragmatic hernia: a narrative review of controversies in neonatal management.Translational pediatrics · 2021Review
- Honeymoon Period in Newborn Rats With CDH Is Associated With Changes in the VEGF Signaling Pathway.Frontiers in pediatrics · 2021Article
- Congenital diaphragmatic hernia: current management strategies from antenatal diagnosis to long-term follow-up.Pediatric surgery international · 2020Review
- Delayed Presentation of Congenital Diaphragmatic Hernia with Acute Respiratory Distress: Challenges in Diagnosis and Management.Case reports in pediatrics · 2020Article
- Surgical management of critical congenital malformations in the delivery room.Seminars in fetal & neonatal medicine · 2019Article
- Congenital diaphragmatic hernia: the good, the bad, and the tough.Pediatric surgery international · 2019Article
- Prenatal Diagnosis of Congenital Diaphragmatic Hernia: Does Laterality Predict Perinatal Outcomes?American journal of perinatology · 2018Article
- Behavioral, emotional and social functioning in children born with congenital diaphragmatic hernia.Pediatric surgery international · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRecent reports suggest that specific care strategies improve survival of infants with congenital diaphragmatic hernia (CDH). This review presents details of care from centers reporting high rates of survival among CDH infants. STUDY
designWe conducted a MEDLINE search (1995 to 2006) and searched all citations in the Cochrane Central Register of Controlled Trials. Studies were included if they contained reports of >20 infants with symptomatic CDH, and >75% survival of isolated CDH.
resultThirteen reports from 11 centers met inclusion criteria. Overall survival, including infants with multiple anomalies, was 603/763 (79%; range: 69 to 93%). Survival for isolated CDH was 560/661 (85%; range: 78 to 96%). The frequency of extracorporeal membrane oxygenation (ECMO) use for isolated CDH varied widely among reporting centers 251/622 (40%; range: 11 to 61%), as did survival for infants with isolated CDH placed on ECMO: 149/206 (73%; range: 33 to 86%). There was no suggestion of benefit from use of antenatal glucocorticoids given after 34 weeks gestation or use of postnatal surfactant. Low mortality was frequently attributed to minimizing lung injury and adhering to center-specific criteria for ECMO.
conclusionUse of strategies aimed at minimizing lung injury, tolerance of postductal acidosis and hypoxemia, and adhering to center-specific criteria for ECMO were strategies most consistently reported by successful centers. The literature lacks randomized clinical trials of these or other care strategies in this complex patient population; prospective studies of safety and long-term outcome are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.