ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2008
Cannabis use disrupts eyeblink conditioning: evidence for cannabinoid modulation of cerebellar-dependent learning.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis.JAMA psychiatry · 2018Pooled it
- Disentangling eye movement desensitization and reprocessing mechanisms of action: The impact of eye movements in the eye blink conditioning task.Psychology and psychotherapy · 2025Trial
- Tests for learning and memory in rodent regulatory studies.Current research in toxicology · 2024Article
- Latent inhibition, aberrant salience, and schizotypy traits in cannabis users.Schizophrenia research. Cognition · 2022Article
- Preliminary Eye-Tracking Data as a Nonintrusive Marker for Blood Δ-9-Tetrahydrocannabinol Concentration and Drugged Driving.Cannabis and cannabinoid research · 2021Article
- Altered cerebellar-cortical resting-state functional connectivity in cannabis users.Journal of psychopharmacology (Oxford, England) · 2021Article
- Differential effects of two early life stress paradigms on cerebellar-dependent delay eyeblink conditioning.Neurobiology of stress · 2020Article
- Polarity- and Intensity-Independent Modulation of Timing During Delay Eyeblink Conditioning Using Cerebellar Transcranial Direct Current Stimulation.Cerebellum (London, England) · 2020Article
- Cannabinoid agonist administration within the cerebellar cortex impairs motor learning.Neurobiology of learning and memory · 2020Review
- Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning.Behavioural brain research · 2020Article
- Assessment of Acute Motor Effects and Tolerance Following Self-Administration of Alcohol and Edible ∆Alcoholism, clinical and experimental research · 2019Article
- Motor Adaptation Impairment in Chronic Cannabis Users Assessed by a Visuomotor Rotation Task.Journal of clinical medicine · 2019Article
- The Cerebellum, THC, and Cannabis Addiction: Findings from Animal and Human Studies.Cerebellum (London, England) · 2019Review
- New vistas on cannabis use disorder.Neuropharmacology · 2017Review
- Cannabinoid modulation of memory consolidation within the cerebellum.Neurobiology of learning and memory · 2016Article
- Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia?The Journal of physiology · 2016Review
- Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Cerebellar endocannabinoids: retrograde signaling from purkinje cells.Cerebellum (London, England) · 2015Review
- Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol.Frontiers in behavioral neuroscience · 2015Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
While the cerebellum contains the highest density of cannabinoid receptor (CB1) in the brain, no studies have assessed the effect of exogenous cannabinoids on cerebellar-dependent learning in humans. The current study, therefore, examined the effect of chronic cannabis use on classical eyeblink conditioning (EBC), a cerebellar-mediated task which has been shown to be disrupted in CB1 knockout mice. Chronic cannabis users (24 h abstinence before study; positive THC urine drug test) free of DSM-IV Axis-I or -II disorders, were evaluated. A delay EBC task was utilized, in which a conditioned stimulus (CS; 400 ms tone) co-terminated with a corneal air puff unconditioned stimulus (US; 50 ms), thus eliciting a conditioned blink response (CR). The cannabis group exhibited markedly fewer, and more poorly timed CRs as compared to drug-naive controls. There were no differences between the groups in either the unconditioned response (UR) or an EEG measure of selective attention to the CS (N100 auditory ERP), indicating that the disruption observed in the cannabis group was specific to CR acquisition. These results suggest that cannabis use is associated with functional deficits in the cerebellar circuitry underlying EBC, a finding which corroborates the recent work in CB1 knockout mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.