ArticleInternational journal of radiation oncology, biology, physics2007
Heritability of susceptibility to ionizing radiation-induced apoptosis of human lymphocyte subpopulations.
Article in International journal of radiation oncology, biology, physics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.International journal of radiation oncology, biology, physics · 2018Trial
- Scientific and Clinical Studies on Variation in Individual Response to Ionising Radiation: A Scoping Review.Cureus · 2026Review
- Senescence-like Phenotype After Chronic Exposure to Isoproterenol in Primary Quiescent Immune Cells.Biomolecules · 2024Article
- Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma.Journal of translational medicine · 2021Article
- Telomere Length Dynamics and Chromosomal Instability for Predicting Individual Radiosensitivity and Risk via Machine Learning.Journal of personalized medicine · 2021Article
- Prediction of the Acute or Late Radiation Toxicity Effects in Radiotherapy Patients Using Ex Vivo Induced Biodosimetric Markers: A Review.Journal of personalized medicine · 2020Review
- The Implications of Genetic Testing on Radiation Therapy Decisions: A Guide for Radiation Oncologists.International journal of radiation oncology, biology, physics · 2019Review
- Radiation biology and oncology in the genomic era.The British journal of radiology · 2018Review
- Role of Germline Genetics in Identifying Survivors at Risk for Adverse Effects of Cancer Treatment.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2018Review
- Radiogenomic Predictors of Adverse Effects following Charged Particle Therapy.International journal of particle therapy · 2018Article
- Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer.Cancers · 2017Review
- TNFSF10/TRAIL regulates human T4 effector memory lymphocyte radiosensitivity and predicts radiation-induced acute and subacute dermatitis.Oncotarget · 2016Article
- Comparison of Individual Radiosensitivity to γ-Rays and Carbon Ions.Frontiers in oncology · 2016Article
- Exploiting biological and physical determinants of radiotherapy toxicity to individualize treatment.The British journal of radiology · 2015Review
- Developmental regulation of p53-dependent radiation-induced thymocyte apoptosis in mice.Clinical and experimental immunology · 2015Article
- Genetic determinants of neuronal vulnerability to apoptosis.Cellular and molecular life sciences : CMLS · 2013Review
- Article
- Genetics and genomics of radiotherapy toxicity: towards prediction.Genome medicine · 2011Article
- Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies.Pharmacogenetics and genomics · 2011Article
- Gene polymorphisms, apoptotic capacity and cancer risk.Human genetics · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate the heritability of intrinsic radiosensitivity, the induction of apoptosis in lymphocyte subpopulations was determined on samples from related individuals belonging to large kindred families. METHODS AND MATERIALS: Quiescent lymphocytes from 334 healthy individuals were gamma-irradiated in vitro. Apoptosis was determined 18 h after irradiation by eight-color flow cytometry. Radiosensitivity was quantified from dose-effect curves. Intrafamilial correlations and heritability were computed for 199 father-mother-offspring trios using the programs SOLAR (Sequential Oligogenic Linkage Analysis Routines) and SAGE (Statistical Analysis for Genetic Epidemiology). Segregation analyses were conducted using SAGE.
resultsMarked differential susceptibility of naive and memory T lymphocytes was demonstrated. Also, although age and gender were significant covariates, their effects only accounted for a minor part of the inter-individual variation. Parent-offspring and sib-sib correlations were significant for the radiosensitivity of B cells, T4, and T8 and of effector memory T4 and T8 subpopulations. In the T4-effector memory subpopulation, the phenotype showed correlations most consistent with dominant or additive genetic effects, and the results of the segregation analysis were consistent with the contribution of a bi-allelic dominant locus.
conclusionsHeritability was demonstrated for the susceptibility to ionizing radiation-induced apoptosis of lymphocyte populations, and the segregation of the T4-effector memory radiosensitivity phenotype was consistent with a simple mendelian transmission model involving one major gene.
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Registered trials
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