ArticleJournal of assisted reproduction and genetics2007
Murine pre-embryo oxygen consumption and developmental competence.
Article in Journal of assisted reproduction and genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- A randomized clinical trial comparing embryo culture in a conventional incubator with a time-lapse incubator.Journal of assisted reproduction and genetics · 2012Trial
- Oocyte Exposure to Low Levels of Triclosan Has a Significant Impact on Subsequent Embryo Physiology.International journal of environmental research and public health · 2025Article
- Dynamic shapes of the zygote and two-cell mouse and human.Biology open · 2021Article
- Real-Time Analysis of Oxygen Gradient in Oocyte Respiration Using a High-Density Microelectrode Array.Biosensors · 2021Article
- Treatment with Laevo (L)-carnitine reverses the mitochondrial function of human embryos.Journal of assisted reproduction and genetics · 2021Article
- Mitochondria Lead the Way: Mitochondrial Dynamics and Function in Cellular Movements in Development and Disease.Frontiers in cell and developmental biology · 2021Review
- Mitochondrial oxygen consumption rate of human embryos declines with maternal age.Journal of assisted reproduction and genetics · 2020Article
- Effects of thyroid hormone on mitochondria and metabolism of human preimplantation embryos.Stem cells (Dayton, Ohio) · 2020Article
- A Preclinical Evaluation towards the Clinical Application of Oxygen Consumption Measurement by CERMs by a Mouse Chimera Model.International journal of molecular sciences · 2019Article
- Quantitative and qualitative changes of mitochondria in human preimplantation embryos.Journal of assisted reproduction and genetics · 2017Article
- Mitochondrial function of human embryo: Decline in their quality with maternal aging.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn search for a new marker of preimplantation embryo viability the present study investigated oxygen consumption of individual cleavage stage murine embryos, and evaluated the predictive value regarding subsequent development to expanded blastocysts.
methodsIn all, 248 embryos were investigated from 2 cell stage until blastocyst stage with individual measurement of oxygen consumption and recording of developmental stage. Cleavage stage embryos and morula were divided in groups according to their oxygen consumption, and odds ratios (OR) for subsequent development to expanded blastocyst were calculated.
resultsCleavage stage (2-8 cell) individual oxygen consumption was 0.16-0.20 nl O(2) h(-1), with a significant increase to 0.21-0.23 nl O(2) h(-1) at the morula stage followed by a more than twofold increase for the expanded blastocyst 0.47 nl O(2) h(-1). A significantly higher chance of reaching the expanded blastocyst stage was found in 4-cell embryos with high oxygen consumption, than embryos with low consumption (OR 2.25, 95% CI 1.04-4.90). Among 2-cell embryos the chance of low and high consumers was not significantly different. The method used in the present study somewhat compromised embryo development (51% blastocyst rate) compared to controls (80% blastocystrate) which could make our results less robust.
conclusionPreliminary data from the present study suggest that oxygen consumption in cleavage stage embryos may be an indicator, but a not a strong predictor, of subsequent development to expanded blastocysts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.