ArticleNucleic acids research2007
Interaction of estrogen receptor alpha with proliferating cell nuclear antigen.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
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- Resveratrol, 4' Acetoxy Resveratrol, R-equol, Racemic Equol or S-equol as Cosmeceuticals to Improve Dermal Health.International journal of molecular sciences · 2017Review
- Estrogen Accelerates Cell Proliferation through Estrogen Receptor α during Rat Liver Regeneration after Partial Hepatectomy.Acta histochemica et cytochemica · 2017Article
- Baicalein has protective effects on the 17β-estradiol-induced transformation of breast epithelial cells.Oncotarget · 2017Article
- Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer.Journal of agricultural and food chemistry · 2014Article
- EF24 prevents rotenone-induced estrogenic status alteration in breast cancer.Cell biology international · 2014Article
- Estrogen signaling and the DNA damage response in hormone dependent breast cancers.Frontiers in oncology · 2014Review
- Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells.Carcinogenesis · 2013Article
- Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells.Molecular and cellular biochemistry · 2011Article
- Long-range transcriptional control of progesterone receptor gene expression.Molecular endocrinology (Baltimore, Md.) · 2010Article
- A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain.The Journal of biological chemistry · 2009Article
- Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Isolation of proteins associated with the DNA-bound estrogen receptor alpha.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Using RNA interference to study protein function.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Isolation of novel coregulatory protein networks associated with DNA-bound estrogen receptor alpha.BMC molecular biology · 2008Article
- The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression.Molecular and cellular endocrinology · 2008Article
- Effects of Cu/Zn superoxide dismutase on estrogen responsiveness and oxidative stress in human breast cancer cells.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.Nucleic acids research · 2008Article
- Two estrogen response element sequences near the PCNA gene are not responsible for its estrogen-enhanced expression in MCF7 cells.PloS one · 2008Article
- PCNA interacts with Prox1 and represses its transcriptional activity.Molecular vision · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The ability of estrogen receptor alpha (ERalpha) to modulate gene expression is influenced by the recruitment of a host of co-regulatory proteins to target genes. To further understand how estrogen-responsive genes are regulated, we have isolated and identified proteins associated with ERalpha when it is bound to DNA containing the consensus estrogen response element (ERE). One of the proteins identified in this complex, proliferating cell nuclear antigen (PCNA), is required for DNA replication and repair. We show that PCNA interacts with ERalpha in the absence and in the presence of DNA, enhances the interaction of ERalpha with ERE-containing DNA, and associates with endogenous estrogen-responsive genes. Interestingly, rather than altering hormone responsiveness of endogenous, estrogen-responsive genes, PCNA increases the basal expression of these genes. Our studies suggest that in addition to serving as a platform for the recruitment of DNA replication and repair proteins, PCNA may serve as a platform for transcription factors involved in regulating gene expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.