ArticleProceedings of the National Academy of Sciences of the United States of America2007
Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 50 citations in OpenAlex.
- Insulin-like Growth Factor 2 Regulates Skeletal Muscle Development in Spotted Sea Bass (Lateolabrax maculatus).Marine biotechnology (New York, N.Y.) · 2026Article
- Article
- Parallel Genomic Changes Drive Repeated Evolution of Placentas in Live-Bearing Fish.Molecular biology and evolution · 2021Article
- Molecular Signatures of Placentation and Secretion Uncovered in Poeciliopsis Maternal Follicles.Molecular biology and evolution · 2020Article
- The Genomes of the Livebearing Fish Species Poeciliopsis retropinna and Poeciliopsis turrubarensis Reflect Their Different Reproductive Strategies.Molecular biology and evolution · 2020Article
- The genome of the live-bearing fish Heterandria formosa implicates a role of conserved vertebrate genes in the evolution of placental fish.BMC evolutionary biology · 2019Article
- A multilocus phylogeny of the fish genusEcology and evolution · 2019Article
- Tissue-Specific Transcriptome forG3 (Bethesda, Md.) · 2018Article
- Asymmetric paternal effect on offspring size linked to parent-of-origin expression of an insulin-like growth factor.Ecology and evolution · 2017Article
- Evidence of positive selection associated with placental loss in tiger sharks.BMC evolutionary biology · 2016Article
- Allelic expression of mammalian imprinted genes in a matrotrophic lizard, Pseudemoia entrecasteauxii.Development genes and evolution · 2016Article
- Rapid molecular evolution across amniotes of the IIS/TOR network.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Identification and computational analysis of gene regulatory elements.Cold Spring Harbor protocols · 2015Review
- Article
- Retroviruses facilitate the rapid evolution of the mammalian placenta.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Functional similarity and molecular divergence of a novel reproductive transcriptome in two male-pregnant Syngnathus pipefish species.Ecology and evolution · 2013Article
- Embryonic IGF2 expression is not associated with offspring size among populations of a placental fish.PloS one · 2012Article
- A phylogenetic approach to test for evidence of parental conflict or gene duplications associated with protein-encoding imprinted orthologous genes in placental mammals.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Divergence of imprinted genes during mammalian evolution.BMC evolutionary biology · 2010Article
- Genomic imprinting of IGF2 in marsupials is methylation dependent.BMC genomics · 2008Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite abundant examples of both adaptation at the level of phenotype and Darwinian selection at the level of genes, correlations between these two processes are notoriously difficult to identify. Positive Darwinian selection on genes is most easily discerned in cases of genetic conflict, when antagonistic evolutionary processes such as a Red Queen race drive the rate of nonsynonymous substitution above the neutral mutation rate. Genomic imprinting in mammals is thought to be the product of antagonistic evolution coincident with evolution of the placenta, but imprinted loci lack evidence of positive selection likely because of the ancient origin of viviparity in mammals. To determine whether genetic conflict is a general feature of adaptation to placental reproduction, we performed comparative evolutionary analyses of the insulin-like growth factor II (IGF2) gene in teleost fishes. Our analysis included several members of the order Cyprinodontiformes, in which livebearing and placentation have evolved several times independently. We found that IGF2 is subject to positive Darwinian selection coincident with the evolution of placentation in fishes, with particularly strong selection among lineages that have evolved placentation recently. Positive selection is also detected along ancient lineages of placental livebearing fishes, suggesting that selection on IGF2 function is ongoing in placental species. Our observations provide a rare example of natural selection acting in synchrony at the phenotypic and molecular level. These results also constitute the first direct evidence of parent-offspring conflict driving gene evolution.
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