ArticleMolecular and cellular biology2007
Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Acetylation modification in malignant progression and therapeutic resistance of gliomas.Frontiers in cell and developmental biology · 2026Review
- The Drosophila histone variant H2Av facilitates Notch signaling activity in a two-tier regulatory fashion.Cell communication and signaling : CCS · 2025Article
- TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex.International journal of oncology · 2021Article
- Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double-strand break.Genetics · 2021Article
- NBS1 interacts with Notch signaling in neuronal homeostasis.Nucleic acids research · 2020Article
- Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase.Journal of biosciences · 2019Article
- The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling.The Journal of biological chemistry · 2019Article
- Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.Journal of experimental & clinical cancer research : CR · 2017Article
- Article
- Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Tat-interactive Protein-60KDA (TIP60) Regulates the Tumorigenesis of Lung Cancer In Vitro.Journal of Cancer · 2017Article
- MDR1 mediated chemoresistance: BMI1 and TIP60 in action.Biochimica et biophysica acta · 2016Article
- Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells.Oncotarget · 2016Article
- NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.Nature reviews. Urology · 2014Review
- Notch1 modulates oxidative stress induced cell death through suppression of apoptosis signal-regulating kinase 1.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein.The Journal of biological chemistry · 2012Article
- Article
- Dual regulation of notch1 signaling pathway by adaptor protein fe65.The Journal of biological chemistry · 2012Article
- Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.Nature · 2011Article
- MYST-family histone acetyltransferases: beyond chromatin.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Notch signaling pathway appears to perform an important function in a wide variety of organisms and cell types. In our present study, we provide evidence that UV irradiation-induced Tip60 proteins reduced Notch1 activity to a marked degree. Accumulated UV irradiation-induced Tip60 suppresses Notch1 transcriptional activity via the dissociation of the Notch1-IC-CSL complex. The binding between endogenous Tip60 and Notch1-IC in UV radiation-exposed cells was verified in this study by coimmunoprecipitation. Interestingly, the physical interaction of Tip60 with Notch1-IC occurs to a more profound degree in the presence of CSL but does not exist in a trimeric complex. Using Notch1-IC and Tip60 deletion mutants, we also determined that the N terminus, which harbors the RAM domain and seven ankyrin repeats of Notch1-IC, interacts with the zinc finger and acetyl coenzyme A domains of Tip60. Furthermore, here we report that Notch1-IC is a direct target of the acetyltransferase activity of Tip60. Collectively, our data suggest that Tip60 is an inhibitor of the Notch1 signaling pathway and that Tip60-dependent acetylation of Notch1-IC may be relevant to the mechanism by which Tip60 suppresses Notch1 signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.