ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Fast regulation of axonal growth cone motility by electrical activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Neuronal growth patterns and synapse formation are mediated by distinct activity-dependent mechanisms.Scientific reports · 2025Article
- Bioengineering strategy to promote CNS nerve growth and regeneration via chronic glutamate signaling.Acta biomaterialia · 2024Article
- Systems of axon-like circuits for self-assembled and self-controlled growth of bioelectric networks.Scientific reports · 2022Article
- Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders.American journal of human genetics · 2021Article
- Advances and Perspectives in Dental Pulp Stem Cell Based Neuroregeneration Therapies.International journal of molecular sciences · 2021Review
- Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala.eLife · 2020Article
- Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1.Molecular neurobiology · 2019Article
- Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance.Physiological reviews · 2017Review
- Axonal Kainate Receptors Modulate the Strength of Efferent Connectivity by Regulating Presynaptic Differentiation.Frontiers in cellular neuroscience · 2016Article
- Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors.The Journal of biological chemistry · 2015Article
- Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines.Molecular biology of the cell · 2015Article
- Retinoic acid induces changes in electrical properties of adult neurons in a dose- and isomer-dependent manner.Journal of neurophysiology · 2014Article
- CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Postsynaptic kainate receptor recycling and surface expression are regulated by metabotropic autoreceptor signalling.Traffic (Copenhagen, Denmark) · 2013Article
- Role of electrical activity in horizontal axon growth in the developing cortex: a time-lapse study using optogenetic stimulation.PloS one · 2013Article
- Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth.Nature neuroscience · 2012Article
- Interleukin-17A increases neurite outgrowth from adult postganglionic sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism.Molecular psychiatry · 2012Article
- Calcium signaling in neuronal development.Cold Spring Harbor perspectives in biology · 2011Review
- Modulation of neurite outgrowth by activation of calcium-permeable kainate receptors expressed by rat nociceptive-like dorsal root ganglion neurons.Developmental neurobiology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axonal growth cones are responsible for the correct guidance of developing axons and the establishment of functional neural networks. They are highly motile because of fast and continuous rearrangements of their actin-rich cytoskeleton. Here we have used live imaging of axonal growth cones of hippocampal neurons in culture and quantified their motility with a temporal resolution of 2 s. Using novel methods of analysis of growth cone dynamics, we show that transient activation of kainate receptors by bath-applied kainate induced a fast and reversible growth cone stalling. This effect depends on electrical activity and can be mimicked by the transient discharge of action potentials elicited in the neuron by intracellular current injections at the somatic level through a patch pipette. Growth cone stalling induced by electrical stimulation is mediated by calcium entry from the extracellular medium as well as by calcium release from intracellular stores that define spatially restricted microdomains directly affecting cytoskeletal dynamics. We propose that growth cone motility is dynamically controlled by transient bursts of spontaneous electrical activity, which constitutes a prominent feature of developing neural networks in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.