ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
D1 dopamine receptor dDA1 is required in the mushroom body neurons for aversive and appetitive learning in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 213 papers.
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213 citing papers in PubMed, 373 citations in OpenAlex.
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- A temporally restricted function of the dopamine receptor Dop1R2 during memory formation.eLife · 2025Article
- In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies.Journal of visualized experiments : JoVE · 2025Article
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- Multiple methods for assessing learning and memory inbioRxiv : the preprint server for biology · 2025Article
- Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons.eLife · 2025Article
- The role of dopamine in foraging decisions in social insects.Frontiers in insect science · 2025Review
- Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.PLoS biology · 2024Article
- Review
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- Active forgetting and neuropsychiatric diseases.Molecular psychiatry · 2024Review
- Cyclic nucleotide-induced bidirectional long-term synaptic plasticity in Drosophila mushroom body.The Journal of physiology · 2024Article
- Octopamine in the mushroom body circuitry for learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
153 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Drosophila has robust behavioral plasticity to avoid or prefer the odor that predicts punishment or food reward, respectively. Both types of plasticity are mediated by the mushroom body (MB) neurons in the brain, in which various signaling molecules play crucial roles. However, important yet unresolved molecules are the receptors that initiate aversive or appetitive learning cascades in the MB. We have shown previously that D1 dopamine receptor dDA1 is highly enriched in the MB neuropil. Here, we demonstrate that dDA1 is a key receptor that mediates both aversive and appetitive learning in pavlovian olfactory conditioning. We identified two mutants, dumb1 and dumb2, with abnormal dDA1 expression. When trained with the same conditioned stimuli, both dumb alleles showed negligible learning in electric shock-mediated conditioning while they exhibited moderately impaired learning in sugar-mediated conditioning. These phenotypes were not attributable to anomalous sensory modalities of dumb mutants because their olfactory acuity, shock reactivity, and sugar preference were comparable to those of control lines. Remarkably, the dumb mutant's impaired performance in both paradigms was fully rescued by reinstating dDA1 expression in the same subset of MB neurons, indicating the critical roles of the MB dDA1 in aversive as well as appetitive learning. Previous studies using dopamine receptor antagonists implicate the involvement of D1/D5 receptors in various pavlovian conditioning tasks in mammals; however, these have not been supported by the studies of D1- or D5-deficient animals. The findings described here unambiguously clarify the critical roles of D1 dopamine receptor in aversive and appetitive pavlovian conditioning.
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