ArticleMolecular biology of the cell2007
A unique element in the cytoplasmic tail of the type II transforming growth factor-beta receptor controls basolateral delivery.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Cholesterol modulates type I/II TGF-β receptor complexes and alters the balance between Smad and Akt signaling in hepatocytes.Communications biology · 2024Article
- A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila.PLoS biology · 2022Article
- Canonical TGFβ Signaling and Its Contribution to Endometrial Cancer Development and Progression-Underestimated Target of Anticancer Strategies.Journal of clinical medicine · 2021Review
- Mouse embryo geometry drives formation of robust signaling gradients through receptor localization.Nature communications · 2019Article
- Article
- Basolateral delivery of the type I transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif.Molecular biology of the cell · 2017Article
- TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism.Molecular biology of the cell · 2017Article
- A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization.Developmental cell · 2016Article
- Signaling Receptors for TGF-β Family Members.Cold Spring Harbor perspectives in biology · 2016Review
- Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation.Developmental cell · 2015Article
- Role of TGF-β receptor III localization in polarity and breast cancer progression.Molecular biology of the cell · 2014Article
- Strategies for exploring TGF-β signaling in Drosophila.Methods (San Diego, Calif.) · 2014Review
- Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome.Molecular biology of the cell · 2013Article
- Basolateral BMP signaling in polarized epithelial cells.PloS one · 2013Article
- Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia.Traffic (Copenhagen, Denmark) · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Transforming growth factor (TGF)-beta receptors stimulate diverse signaling processes that control a wide range of biological responses. In polarized epithelia, the TGFbeta type II receptor (T2R) is localized at the basolateral membranes. Sequential cytoplasmic truncations resulted in receptor missorting to apical surfaces, and they indicated an essential targeting element(s) near the receptor's C terminus. Point mutations in the full-length receptor confirmed this prediction, and a unique basolateral-targeting region was elucidated between residues 529 and 538 (LTAxxVAxxR) that was distinct, but colocalized within a clinically significant signaling domain essential for TGFbeta-dependent activation of the Smad2/3 cascade. Transfer of a terminal 84 amino-acid fragment, containing the LTAxxVAxxR element, to the apically sorted influenza hemagglutinin (HA) protein was dominant and directed basolateral HA expression. Although delivery to the basolateral surfaces was direct and independent of any detectable transient apical localization, fluorescence recovery after photobleaching demonstrated similar mobility for the wild-type receptor and a missorted mutant lacking the targeting motif. This latter finding excludes the possibility that the domain acts as a cell membrane retention signal, and it supports the hypothesis that T2R sorting occurs from an intracellular compartment.
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Registered trials
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