ArticleMolecular biology of the cell2007
putzig is required for cell proliferation and regulates notch activity in Drosophila.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Characterization of core promoter activation by the Drosophila insulator-binding protein BEAF.Scientific reports · 2025Article
- The Drosophila histone variant H2Av facilitates Notch signaling activity in a two-tier regulatory fashion.Cell communication and signaling : CCS · 2025Article
- Article
- The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization.Nucleic acids research · 2024Article
- The Membrane-Bound Notch Regulator Mnr Supports Notch Cleavage and Signaling Activity inBiomolecules · 2021Article
- Article
- The Chriz Protein Promotes the Recruitment of the Z4 Protein to the STAT-Dependent Promoters.Doklady. Biochemistry and biophysics · 2020Article
- Loss of putzig in the germline impedes germ cell development by inducing cell death and new niche like microenvironments.Scientific reports · 2019Article
- Overexpression of theHereditas · 2018Article
- Bacteriocyte Reprogramming to Cope With Nutritional Stress in a Phloem Sap Feeding Hemipteran, the Pea AphidFrontiers in physiology · 2018Article
- Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity.Scientific reports · 2017Article
- Regulatory Enhancer-Core-Promoter Communication via Transcription Factors and Cofactors.Trends in genetics : TIG · 2016Review
- Article
- Loss of putzig Activity Results in Apoptosis during Wing Imaginal Development in Drosophila.PloS one · 2015Article
- Ultrasensitive proteome analysis using paramagnetic bead technology.Molecular systems biology · 2014Article
- E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila.Journal of cell science · 2014Article
- The Drosophila enhancer of split gene complex: architecture and coordinate regulation by notch, cohesin, and polycomb group proteins.G3 (Bethesda, Md.) · 2013Article
- CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development.Development (Cambridge, England) · 2013Article
- The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART.Mobile DNA · 2013Article
- The chromosomal proteins JIL-1 and Z4/Putzig regulate the telomeric chromatin in Drosophila melanogaster.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified the gene putzig (pzg) as a key regulator of cell proliferation and of Notch signaling in Drosophila. pzg encodes a Zn-finger protein that was found earlier within a macromolecular complex, including TATA-binding protein-related factor 2 (TRF2)/DNA replication-related element factor (DREF). This complex is involved in core promoter selection, where DREF functions as a transcriptional activator of replication-related genes. Here, we provide the first in vivo evidence that pzg is required for the expression of cell cycle and replication-related genes, and hence for normal developmental growth. Independent of its role in the TRF2/DREF complex, pzg acts as a positive regulator of Notch signaling that may occur by chromatin activation. Down-regulation of pzg activity inhibits Notch target gene activation, whereas Hedgehog (Hh) signal transduction and growth regulation are unaffected. Our findings uncover different modes of operation of pzg during imaginal development of Drosophila, and they provide a novel mechanism of Notch regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.