Evidence map›Paper›PMID 17634231›Full record

ArticleJournal of virology2007

Epstein-Barr virus latent nuclear antigens can induce metastasis in a nude mouse model.

Rajeev Kaul, Masanao Murakami, Tathagata Choudhuri, Erle S Robertson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 70 citations in OpenAlex.

  1. Review
  2. Journal of tropical medicine · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Oncogenic Epstein-Barr virus recruits Nm23-H1 to regulate chromatin modifiers.Laboratory investigation; a journal of technical methods and pathology · 2018
    Review
  10. The NDPK/NME superfamily: state of the art.Laboratory investigation; a journal of technical methods and pathology · 2018
    Article
  11. Article
  12. Epstein-Barr virus infection and nasopharyngeal carcinoma.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Review
  13. Article
  14. Review
  15. The Role of Gammaherpesviruses in Cancer Pathogenesis.Pathogens (Basel, Switzerland) · 2016
    Review
  16. Review
  17. Article
  18. Epstein-Barr virus latent antigens EBNA3C and EBNA1 modulate epithelial to mesenchymal transition of cancer cells associated with tumor metastasis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
  19. Review
  20. Regulation of the metastasis suppressor Nm23-H1 by tumor viruses.Naunyn-Schmiedeberg's archives of pharmacology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rajeev KaulDepartment of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA.
Masanao Murakami
Tathagata Choudhuri
Erle S Robertson
University of Pennsylvania · US

Funding

Mechanisms of Action of LANA encoded by KSHVR01CA091792 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROBERTSON, ERLE S. · 2002 to 2011
$3.4M
Mechanism of EBNA mediated cell migrationR01CA108461 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROBERTSON, ERLE S. · 2004 to 2008
$1.7M
EBV Associated Head and Neck CancersR01DE014136 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI ROBERTSON, ERLE S · 2001 to 2005
$1.4M
NCI NIH HHS CA072510NCI NIH HHS CA091792NCI NIH HHS CA108461NCI NIH HHS R01 CA091792NCI NIH HHS R01 CA108461NIDCR NIH HHS DE014136NIDCR NIH HHS R01 DE014136
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus associated with the development of both lymphoid and epithelial tumors. The EBV critical latent antigens EBNA1 and EBNA3C interact with Nm23-H1, a known suppressor of cell migration and tumor metastasis. This interaction is critical for the regulation of downstream cellular genes involved in tumorigenesis and cell migration. The significance of these interactions was determined in nude mice using cancer cells expressing both EBV antigens and Nm23-H1. The EBV antigens promoted the growth of transformed cells in vivo, but their expression was less critical during the later stage of tumor development. The expression of Nm23-H1 affected the growth of cancer cells and suppressed their metastatic potential. This effect was effectively rescued by the expression of both EBV antigens. Interestingly, the prometastatic potential of EBNA3C was greater than that of EBNA1, which triggered a dramatic immune response, as indicated by increased spleen size and development of ascites in the mice. These studies now bridge the expression of the EBV antigens with tumorigenesis and metastasis and widen the range of potential targets for development of therapies for EBV-associated malignancies.

Indexed as

Cell MovementAnimalsAntigens, ViralCell Transformation, NeoplasticEpstein-Barr Virus Nuclear AntigensHumansMiceMice, NudeModels, AnimalNeoplasm MetastasisNeoplasmsNM23 Nucleoside Diphosphate KinasesNucleoside-Diphosphate KinaseAntigens, ViralEBNA-3C, epstein-barr virusEBV-encoded nuclear antigen 1Epstein-Barr Virus Nuclear AntigensNM23 Nucleoside Diphosphate KinasesNME1 protein, humanNme1 protein, mouseNucleoside-Diphosphate Kinase

Identifiers

PMID17634231
PMCPMC2045452
OpenAlexW2066788548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.