ReviewArthritis research & therapy2007
Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies.
Review in Arthritis research & therapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03534999 (Effect of Transcutaneous Electrical Nerve Stimulation on Pain Intensity of Patients With Hip Arthroplasty), which is not on this map. Cited by 189 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Transcutaneous Electrical Nerve Stimulation on Pain Intensity of Patients With Hip Arthroplasty: A Randomized Control Trial
Who cites it
189 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Highly cross-linked polyethylene in primary total knee arthroplasty is associated with a lower rate of revision for aseptic loosening: a meta-analysis of 962,467 cases.Archives of orthopaedic and trauma surgery · 2022Pooled it
- Total elbow arthroplasty in patients with rheumatoid arthritis.The bone & joint journal · 2020Pooled it
- Detection of aseptic loosening in total knee replacements: a systematic review and meta-analysis.Skeletal radiology · 2019Pooled it
- Prosthesis design of animal models of periprosthetic joint infection following total knee arthroplasty: A systematic review.PloS one · 2019Pooled it
- No clinical difference between TiN-coated versus uncoated cementless CoCrMo mobile-bearing total knee arthroplasty; 10-year follow-up of a randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Trial
- Biomimetic nanodelivery of antagomiR-155-5p ameliorates wear particle-induced osteolysis by dual regulation of Gas6/Axl-mediated macrophage inflammation.Journal of orthopaedic translation · 2026Article
- Long-Term Incidence of Peri-Implant Conditions: 25-Year Results of The Bernese Prospective Cohort Study.Clinical implant dentistry and related research · 2026Article
- Synergistic effects of lipopolysaccharide and titanium ions on monocytic myeloid-derived suppressor cell expansion in gingival tissue: implications for peri-implant bone health.Journal of periodontal & implant science · 2026Article
- Early Outcomes of a Novel Collared Triple-Tapered Femoral System in Primary Total Hip Arthroplasty.Medicina (Kaunas, Lithuania) · 2026Article
- Nanoparticle-Loaded Injectable Hydrogel Alleviates Titanium Particle-Induced Osteolysis by Disrupting GATA6/DDX3X-Mediated Macrophage Inflammation.Biomaterials research · 2026Article
- Long-term Performance and Durability of Biomaterials and Implant Designs in Total Joint Arthroplasty and Spinal Fusion.Journal of orthopaedics and sports medicine · 2026Article
- Magnesium-containing implants enhance bone healing: A mechanobiological perspective.Mechanobiology in medicine · 2025Review
- Longitudinal monitoring of bone remodelling activity around the acetabular cup after total hip arthroplasty using 18F-fluoride PET/CT scans.Bone & joint research · 2025Article
- Advancements and current trends in bearing surface technology for total shoulder arthroplasty: a comprehensive review.JSES reviews, reports, and techniques · 2025Review
- Nano-size tantalum particles suppress the osteogenic activity of osteoblasts and stimulate osteoclasts.Journal of biological engineering · 2025Article
- Advancements in Biomedical Sensors for Early Detection of Failure in Hip and Knee Implants: Scoping Review on Potential Sensors for Implant Integration.Annals of biomedical engineering · 2025Article
- Is Collum Femoris Preserving Stem (CFP) an Epiphyseal-Stabilized Prosthesis? A Long-Term Single-Center Series Follow Up of 705 Cases.Orthopaedic surgery · 2025Article
- Risk Factors of Aseptic Loosening After Total Hip Arthroplasty With Collum Femoris Preserving Stem: A Long-Term Follow-Up Study.Orthopaedic surgery · 2025Article
- No difference in reoperation rates or aseptic loosening following cemented total knee arthroplasty with or without a tourniquet.Archives of orthopaedic and trauma surgery · 2025Article
- Modification of low nickel biograde stainless steel with graphene oxide for enhanced corrosion resistance and in vivo biocompatibility.Scientific reports · 2025Article
129 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant-associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant-bone interface is manifested by recruitment of a wide array of cell types. These cells include macrophages, fibroblasts, giant cells, neutrophils, lymphocytes, and--most importantly--osteoclasts, which are the principal bone resorbing cells. The 'cellular response' entails secretion of osteoclastogenic and inflammatory cytokines that favor exacerbated osteoclast activity and enhanced osteolysis. An appreciation of the complex network that leads to these cellular and inflammatory responses will form a foundation on which to develop therapeutic interventions to combat inflammatory periprosthetic bone loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.