ArticleNeural development2007
Lola regulates Drosophila olfactory projection neuron identity and targeting specificity.
Article in Neural development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 54 citations in OpenAlex.
- Chemoreceptor co-expression ineLife · 2022Article
- Susceptibility of the Non-Targeted CrustaceanGenes · 2021Article
- Untangling the wires: development of sparse, distributed connectivity in the mushroom body calyx.Cell and tissue research · 2021Review
- Mitochondrial-Y chromosome epistasis inProceedings. Biological sciences · 2020Article
- Article
- Monitoring food preference inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Neurodevelopmental disorder-associated ZBTB20 gene variants affect dendritic and synaptic structure.PloS one · 2018Article
- cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Orthodenticle is required for the development of olfactory projection neurons and local interneurons in Drosophila.Biology open · 2014Article
- Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila.Genetics · 2014Article
- Dendrite architecture organized by transcriptional control of the F-actin nucleator Spire.Development (Cambridge, England) · 2014Article
- De novo assembly and transcriptome analysis of the Mediterranean fruit fly Ceratitis capitata early embryos.PloS one · 2014Article
- Review
- Cell-intrinsic drivers of dendrite morphogenesis.Development (Cambridge, England) · 2013Review
- Odd-skipped labels a group of distinct neurons associated with the mushroom body and optic lobe in the adult Drosophila brain.The Journal of comparative neurology · 2013Article
- Meigo governs dendrite targeting specificity by modulating ephrin level and N-glycosylation.Nature neuroscience · 2013Article
- The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis.Developmental biology · 2013Article
- The SUMO protease Verloren regulates dendrite and axon targeting in olfactory projection neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Lola regulates glutamate receptor expression at the Drosophila neuromuscular junction.Biology open · 2012Article
- The BTB/POZ zinc finger protein Broad-Z3 promotes dendritic outgrowth during metamorphic remodeling of the peripheral stretch receptor dbd.Neural development · 2011Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrecise connections of neural circuits can be specified by genetic programming. In the Drosophila olfactory system, projection neurons (PNs) send dendrites to single glomeruli in the antenna lobe (AL) based upon lineage and birth order and send axons with stereotyped terminations to higher olfactory centers. These decisions are likely specified by a PN-intrinsic transcriptional code that regulates the expression of cell-surface molecules to instruct wiring specificity.
resultsWe find that the loss of longitudinals lacking (lola), which encodes a BTB-Zn-finger transcription factor with 20 predicted splice isoforms, results in wiring defects in both axons and dendrites of all lineages of PNs. RNA in situ hybridization and quantitative RT-PCR suggest that most if not all lola isoforms are expressed in all PNs, but different isoforms are expressed at widely varying levels. Overexpression of individual lola isoforms fails to rescue the lola null phenotypes and causes additional phenotypes. Loss of lola also results in ectopic expression of Gal4 drivers in multiple cell types and in the loss of transcription factor gene lim1 expression in ventral PNs.
conclusionOur results indicate that lola is required for wiring of axons and dendrites of most PN classes, and suggest a need for its molecular diversity. Expression pattern changes of Gal4 drivers in lola-/- clones imply that lola normally represses the expression of these regulatory elements in a subset of the cells surrounding the AL. We propose that Lola functions as a general transcription factor that regulates the expression of multiple genes ultimately controlling PN identity and wiring specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.