Trial reportBMC neurology2007
Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial.
Trial report in BMC neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00361205 (Electronic Compliance Monitoring in Parkinson's Disease), which is not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electronic Compliance Monitoring in Parkinson's Disease
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Intervention components in the self-management of Parkinson's: a mixed-methods synthesis of qualitative and quantitative evidence.BMC health services research · 2024Pooled it
- Systematic review and meta-analysis of clinical effectiveness of self-management interventions in Parkinson's disease.BMC geriatrics · 2022Pooled it
- Clinical aspects of adherence to pharmacotherapy in Parkinson disease: A PRISMA-compliant systematic review.Medicine · 2018Pooled it
- Pooled it
- Trial
- Trial
- Supporting Medication Adherence in Parkinson's Through Education: A Scoping Review of Interventions.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Exploring medication experiences, behaviours, and reminder technology preferences in people with Parkinson's disease: a survey.Frontiers in digital health · 2026Article
- The impact of the socioeconomic factor on Parkinson's disease medication adherence: a scoping review.Arquivos de neuro-psiquiatria · 2024Article
- How Information Affects Patients with Parkinson's Disease: A Scoping Review of the Literature.Journal of Parkinson's disease · 2024Article
- Association between physical activity and health literacy in patients with Parkinson's disease: an online web survey.BMC neurology · 2023Article
- Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's Disease.Frontiers in neurology · 2020Article
- Continuous Drug Delivery Aiming Continuous Dopaminergic Stimulation in Parkinson's Disease.Journal of Parkinson's disease · 2018Review
- Medication Therapy Management Service for Patients with Parkinson's Disease: A Before-and-After Study.Neurology and therapy · 2016Article
- The impact of patient support programs on adherence, clinical, humanistic, and economic patient outcomes: a targeted systematic review.Patient preference and adherence · 2016Review
- Medication adherence in patients with Parkinson's disease.CNS drugs · 2015Review
- Patient-centered interventions to improve medication management and adherence: a qualitative review of research findings.Patient education and counseling · 2014Review
- Medication nonadherence in Parkinson's disease.Current neurology and neuroscience reports · 2013Review
- Relations between cognitive status and medication adherence in patients treated for memory disorders.Ageing research · 2012Article
- Tailored Information and Automated Reminding to Improve Medication Adherence in Spanish- and English-Speaking Elders Treated for Memory Impairment.Clinical gerontologist · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedicine usage in Parkinson's disease patients is often imperfect, in particular irregular timing of medication. The effect of informing Parkinson's disease patients about the continuous dopaminergic hypothesis (to encourage regular medicine intake) on medication adherence and motor control was tested.
methodsPatients were randomised either to the active group (receiving the intervention) or control group (no extra information). Antiparkinson medicine usage was monitored for 3 months before and after the intervention using electronic pill bottles which record the date and time of opening (MEMS, Aardex, Switzerland) and data used to calculate the percentage of doses taken at correct time intervals.
results43 patients (52%) were randomised to active counselling, and 40 (48%) were controls (standard management). The intervention effect (difference in timing adherence pre- to post-intervention between the 2 groups) was 13.4% (CI 5.1 to 21.7), p = 0.002. Parkinson motor scores did not change significantly (active group 0.1, CI -3.4 to 3.7) versus controls (4.5, CI 1.6 to 7.1), p = 0.06.
conclusionTiming adherence, but not motor scores, improves by providing patients with extra information. Therapy timing is of potential importance in Parkinson's disease management. TRIAL REGISTRATION NUMBER: NCT00361205.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.