Evidence map›Paper›PMID 17634094›Full record

ArticleBMC cell biology2007

Model based dynamics analysis in live cell microtubule images.

Alphan Altinok, Erkan Kiris, Austin J Peck, Stuart C Feinstein, Leslie Wilson, B S Manjunath, Kenneth Rose

Abstract read
In one paragraph

Article in BMC cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. EXTRACTION AND ANALYSIS OF ACTIN NETWORKS BASED ON OPEN ACTIVE CONTOUR MODELS.Proceedings. IEEE International Symposium on Biomedical Imaging · 2011
    Article
  5. Actin filament segmentation using dynamic programming.Information processing in medical imaging : proceedings of the ... conference · 2011
    Article
  6. Article
  7. A generative model of microtubule distributions, and indirect estimation of its parameters from fluorescence microscopy images.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2010
    Article
  8. Actin filament segmentation using spatiotemporal active-surface and active-contour models.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2010
    Article
  9. Review
  10. Bioimage informatics: a new area of engineering biology.Bioinformatics (Oxford, England) · 2008
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alphan AltinokDepartment of Electrical and Computer Engineering, University of California Santa Barbara, CA 93106, USA. alphan@ece.ucsb.edu
Erkan Kiris
Austin J Peck
Stuart C Feinstein
Leslie Wilson
B S Manjunath
Kenneth Rose

Funding

Mechanism &Control of Brain Microtubule DynamicsR01NS013560 · NINDS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI WILSON, LESLIE · 1985 to 2009
$2.9M
The Molecular Structure and Function of Tau ProteinR01NS035010 · NINDS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI FEINSTEIN, STUART C · 1996 to 2010
$2.7M
NINDS NIH HHS R01 NS013560NINDS NIH HHS R01 NS035010NINDS NIH HHS R0I NS13560NINDS NIH HHS R0I NS35010
6 · The paper itself

Abstract

backgroundThe dynamic growing and shortening behaviors of microtubules are central to the fundamental roles played by microtubules in essentially all eukaryotic cells. Traditionally, microtubule behavior is quantified by manually tracking individual microtubules in time-lapse images under various experimental conditions. Manual analysis is laborious, approximate, and often offers limited analytical capability in extracting potentially valuable information from the data.

resultsIn this work, we present computer vision and machine-learning based methods for extracting novel dynamics information from time-lapse images. Using actual microtubule data, we estimate statistical models of microtubule behavior that are highly effective in identifying common and distinct characteristics of microtubule dynamic behavior.

conclusionComputational methods provide powerful analytical capabilities in addition to traditional analysis methods for studying microtubule dynamic behavior. Novel capabilities, such as building and querying microtubule image databases, are introduced to quantify and analyze microtubule dynamic behavior.

Indexed as

Microtubule-Associated ProteinsModels, StatisticalCluster AnalysisImage Processing, Computer-AssistedKineticsMicroscopy, FluorescenceMicrotubulesModels, BiologicalMicrotubule-Associated Proteins

Identifiers

PMID17634094
PMCPMC1924509

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.