ReviewActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2006
Molecular metastases markers in head and neck squamous cell carcinoma: review of the literature.
Review in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.Investigational new drugs · 2013Trial
- A New Model to Investigate the Action of Radiation and Cigarette Smoke on Head and Neck Cancer Cells.Cancers · 2025Article
- Unveiling the therapeutic potential of thymol from Nigella sativa L. seed: selective anticancer action against human breast cancer cells (MCF-7) through down-regulation of Cyclin D1 and proliferative cell nuclear antigen (PCNA) expressions.Molecular biology reports · 2024Article
- Expression of CD44 (NKI-P1) in oral squamous cell carcinoma associated vascular endothelial cells: A relationship to tumor angiogenesis.The Saudi dental journal · 2022Article
- MED15, transforming growth factor beta 1 (TGF-β1), FcγRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma.Scientific reports · 2020Article
- Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases.BioMed research international · 2020Article
- Development of clinico-histopathological predictive model for the assessment of metastatic risk of oral squamous cell carcinoma.Journal of carcinogenesis · 2020Article
- Clinical, pathophysiologic, and genomic analysis of the outcomes of primary head and neck malignancy after pulmonary metastasectomy.Scientific reports · 2019Article
- Review
- Role of E-cadherin and cyclin D1 as predictive markers of aggression and clonal expansion in head and neck squamous cell carcinoma.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2018Article
- Pathologic significance of AKT, mTOR, and GSK3β proteins in oral squamous cell carcinoma-affected patients.Virchows Archiv : an international journal of pathology · 2018Article
- Low Lymphatic Vessel Density Correlates with Lymph Node Metastasis in Oral Squamous Cell Carcinoma.Journal of dentistry (Shiraz, Iran) · 2018Article
- VEGF and CD 34: A correlation between tumor angiogenesis and microvessel density-an immunohistochemical study.Journal of oral and maxillofacial pathology : JOMFP · 2013Article
- VEGF: A critical driver for angiogenesis and subsequent tumor growth: An IHC study.Journal of oral and maxillofacial pathology : JOMFP · 2012Article
- Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells.Journal of cancer research and clinical oncology · 2012Article
- Recently identified biomarkers that promote lymph node metastasis in head and neck squamous cell carcinoma.Cancers · 2011Article
- EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma.Current health sciences journalArticle
- Study of expression of endoglin (CD105) in oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
- Comparative immunohistochemical expression of transforming growth factor beta one (TGF-β1) in oral epithelial dysplasia and oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is now widely accepted that the presence of lymph node metastases is a negative prognostic factor in head and neck squamous cell carcinoma. It follows that the ability to determine the presence of micro-metastases or the metastatic potential of a tumour at an early stage would condition the therapeutic strategy and evolution of this type of tumour. Prediction of the metastatic potential of head and neck squamous cell carcinoma is still, today, entrusted to clinical and histological evaluation of the tumour. However, the high percentage of relapse in this tumour shows the inadequacy of these parameters in predicting metastatic potential. Furthermore, progress made over the last ten years in understanding the molecular mechanisms involved in the process of neoplastic tumour progression has led to the identification of molecules that can be used as potential prognostic markers of head and neck squamous cell carcinoma. There are many molecules involved in the process of forming metastases. This process represents the final stage of a multistep model, in which alterations occur to genes that are important for growth, proliferation and migration, to which are added variations in the expression of molecules involved in the process of homeostasis of the extra-cellular matrix, of angiogenesis and lymphangiogenesis, favouring tumour invasion and the formation of metastases. This review of the literature shows that the tumour invasion process is associated with numerous molecular alterations that might be used as potential prognostic molecular markers. However, none of these alterations is univocally associated with the metastasization used in clinical practice. Further studies on larger series and on a larger scale, such as genome studies, and preclinical studies on markers used as targets in specific therapies, will provide a valuable contribution to their use in clinical practice in the short term.
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17633150PMC2639992W1555748218What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.