ArticleBiochemical pharmacology2007
Delay of cutaneous wound closure by morphine via local blockade of peripheral tachykinin release.
Article in Biochemical pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Topical application of morphine for wound healing and analgesia in patients with oral lichen planus: a randomized, double-blind, placebo-controlled study.Clinical oral investigations · 2018Trial
- Topical morphine gel in the treatment of painful leg ulcers, a double-blind, placebo-controlled clinical trial: a pilot study.International wound journal · 2012Trial
- Review
- Future roles of artificial intelligence in early pain management of newborns.Paediatric & neonatal pain · 2021Review
- The Altered Migration and Distribution of Systemically Administered Mesenchymal Stem Cells in Morphine-Treated Recipients.Stem cell reviews and reports · 2021Article
- Tissue Regeneration: The Dark Side of Opioids.International journal of molecular sciences · 2021Review
- Keratin Scaffolds Containing Casomorphin Stimulate Macrophage Infiltration and Accelerate Full-Thickness Cutaneous Wound Healing in Diabetic Mice.Molecules (Basel, Switzerland) · 2021Article
- Expression of Opioid Receptors in Cells of the Immune System.International journal of molecular sciences · 2020Review
- Bidirectional Regulation of Opioid and Chemokine Function.Frontiers in immunology · 2020Review
- The Impact of Morphine on the Characteristics and Function Properties of Human Mesenchymal Stem Cells.Stem cell reviews and reports · 2018Article
- Local Resiniferatoxin Induces Long-Lasting Analgesia in a Rat Model of Full Thickness Thermal Injury.Pain medicine (Malden, Mass.) · 2017Article
- Burn wound healing and treatment: review and advancements.Critical care (London, England) · 2015Review
- Anesthesia, microcirculation, and wound repair in aging.Anesthesiology · 2014Review
- Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Surgically induced neuropathic pain: understanding the perioperative process.Annals of surgery · 2013Review
- Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression.Biochemical pharmacology · 2009Article
- Temporal effects of topical morphine application on cutaneous wound healing.Anesthesiology · 2008Article
- Buprenorphine blunts inflammatory response and wound progression after skin exposure to nitrogen mustard.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Topically applied morphine is routinely used to alleviate pain in cutaneous wounds such as burns and pressure sores. Evidence suggests the topical administration of exogenous opioid drugs may impair wound closure. This study examined the effects of topical morphine on a standardized model of cutaneous wound healing in the rat. Full-thickness 4mm diameter circular skin flaps were excised from the intrascapular region of male Sprague-Dawley rats. IntraSite Gel infused with either morphine-sulfate, neurokinin-1 (NK-1) or neurokinin-2 (NK-2) receptor antagonists, substance P (SP), neurokinin A (NKA), SP+morphine-sulfate, or NKA+morphine-sulfate was applied to the wound twice daily. Results demonstrated a significant overall delay in the time course of wound contraction in morphine-treated animals when compared with gel-only treated controls. The delay in wound contraction seen in morphine-treated animals increased in a concentration-dependent manner. Topical application of NK-1 or NK-2 receptor antagonists mimicked the effects of morphine in delaying wound closure, suggesting topical opioids impair wound closure via the inhibition of SP and NKA release peripherally into the healing wound. Additionally, no significant delays in closure were seen in rats receiving morphine combined with SP or NKA, demonstrating the ability of each neuropeptide to attenuate the effects of morphine in delaying wound closure and restore normal wound closure rates. The combination of SP or NKA and morphine-sulfate for wound therapy may provide local analgesia while maintaining normal closure rates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.