ArticleBiophysical journal2007
Dynamic patches of membrane proteins.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Homotypic and heterotypicCurrent research in immunology · 2022Review
- Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation.PLoS pathogens · 2020Article
- Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Membrane Diffusion Occurs by Continuous-Time Random Walk Sustained by Vesicular Trafficking.Biophysical journal · 2018Article
- The Life of a Membrane Protein.Biophysical journal · 2018Article
- Article
- MreB-Dependent Organization of the E. coli Cytoplasmic Membrane Controls Membrane Protein Diffusion.Biophysical journal · 2016Article
- Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling.The Journal of cell biology · 2016Review
- Sphingolipid Organization in the Plasma Membrane and the Mechanisms That Influence It.Frontiers in cell and developmental biology · 2016Review
- Sensing Size through Clustering in Non-Equilibrium Membranes and the Control of Membrane-Bound Enzymatic Reactions.PloS one · 2015Article
- Update of the 1972 Singer-Nicolson Fluid-Mosaic Model of Membrane Structure.Discoveries (Craiova, Romania) · 2013Review
- Plasma membrane organization and function: moving past lipid rafts.Molecular biology of the cell · 2013Article
- Sphingolipid domains in the plasma membranes of fibroblasts are not enriched with cholesterol.The Journal of biological chemistry · 2013Article
- Size of cell-surface Kv2.1 domains is governed by growth fluctuations.Biophysical journal · 2012Article
- Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Lifetime of major histocompatibility complex class-I membrane clusters is controlled by the actin cytoskeleton.Biophysical journal · 2012Article
- Class I MHC molecules as probes of membrane patchiness: from biophysical measurements to modulation of immune responses.Immunologic research · 2010Review
- Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We test here a previously proposed hypothesis about lateral heterogeneity of cell membranes, a model predicting that heterogeneity is maintained by a combination of delivery and intake of molecules with barriers to lateral free diffusion. To test the validity of the model, we observed green fluorescent protein tagged major histocompatibility complex class I patches on the plasma membrane of mouse fibroblasts, using total internal reflection fluorescence microscopy in real time. The dynamic characterization revealed the life course of these patches comprises delivery of molecules at a short instant, followed by a slow, exponential decay, corresponding to diffusion of the molecules over dynamic barriers to free lateral diffusion. The characteristic lifetime of the patches, extracted from the measurements, is approximately 30 s, in excellent agreement with the predictions of the model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.