Evidence map›Paper›PMID 17631228›Full record

ReviewClinics in geriatric medicine2007

Host resistance and immune responses in advanced age.

Steven C Castle, Koichi Uyemura, Tamas Fulop, Takashi Makinodan

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinics in geriatric medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 121 citations in OpenAlex.

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  16. Carbapenem-ResistantClinical interventions in aging · 2023
    Article
  17. Article
  18. Small animal models of thermal injury.Methods in cell biology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Steven C CastleGeriatric Research Education and Clinical Center (GRECC) (mail code 11G), VA Greater Los Angeles Healthcare System, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. steven.castle@med.va.gov
Koichi Uyemura
Tamas Fulop
Takashi Makinodan
Geriatric Research Education and Clinical Center · USUniversité de Sherbrooke · CAVA Greater Los Angeles Healthcare System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunosenescence results in populating immune tissues with less functional T cells, and perhaps B cells dendritic cells, that do not function well and produce more type 2 cytokines and fewer type 1 cytokines. Impaired immunity, distinct from immunosenescence, correlates more with disease burden than chronologic age. Older adults who have chronic diseases or chronic infections are more susceptible to common infections and have poor vaccine responses. Understanding specific mechanisms and targeting interventions are dependent on research to resolve the relationship between frailty-associated impaired immunity and the role of chronic infection versus immunosenescence in developing impaired immunity.

Indexed as

Immunity, CellularAgedAged, 80 and overAgingHumansImmunocompromised HostRisk Factors

Identifiers

PMID17631228
PMCPMC7135540
OpenAlexW2067026617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.