ReviewCNS drugs2007
CNS aspergillosis: recognition, diagnosis and management.
Review in CNS drugs, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Treatment of invasive fungal infections in cancer patients-updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO).Annals of hematology · 2014Guideline
- An unusual case of invasive rhino-cerebral aspergillosis in a pediatric patient: A case report with diagnostic approach and imaging review.Radiology case reports · 2026Article
- Epidemiology of Aspergillosis Diagnoses in US Adults Using a National EHR Database, 2013-2023.Open forum infectious diseases · 2026Article
- A rare cause of obstructive hydrocephalus: Cerebral aspergillosis presenting as an intracranial space-occupying lesion in an immunocompetent adult.Surgical neurology international · 2025Article
- Intracranial fungal mass imitating a high-grade glial lesion - is antifungal alone sufficient?Surgical neurology international · 2025Article
- Imaging Findings in Aspergillosis: From Head to Toe.Mycopathologia · 2023Review
- Case Report and Clinical Reasoning: Fulminant Liver Failure and Invasive Aspergillosis Following Ocrelizumab Treatment in a 21 Year-Old Woman.The Neurohospitalist · 2023Article
- Isavuconazole Treatment of Spinal Cord Invasive Aspergillosis Guided by Cerebrospinal Fluid (1,3)-β-d-Glucan Levels in a Patient with Low Interferon-Gamma and Ulcerative Colitis.Journal of fungi (Basel, Switzerland) · 2022Article
- Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Cerebral Aspergillosis.Frontiers in microbiology · 2021Article
- Interaction Between the Complement System and Infectious Agents - A Potential Mechanistic Link to Neurodegeneration and Dementia.Frontiers in cellular neuroscience · 2021Review
- Infections in the immunocompromised child.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Review
- Fungal infections in pediatric neurosurgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Review
- Diagnosis of Vitreoretinal Aspergillosis with Transvitreal Retinochoroidal Biopsy.Case reports in ophthalmological medicine · 2018Article
- [Aspergillus in airway material : Ignore or treat?]Der Internist · 2017Review
- Review
- Intracranial Aspergillosis in an Immunocompetent Young Woman.Mycopathologia · 2017Article
- [Cervical aspergillosis with dissemination to the central nervous system: Case reports and review of the literature].Surgical neurology international · 2015Article
- True mycotic aneurysm in a patient with gonadotropinoma after trans-sphenoidal surgery.Surgical neurology international · 2015Article
- [Molecular biological identification of fungal pathogens in FFPE tissue from cases of cephalic mycosis].Der Pathologe · 2013Review
- Cerebral aspergillosis with multiple enhancing nodules in the right cerebral hemisphere in the immune-competent patient.Journal of Korean Neurosurgical Society · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early diagnosis of CNS aspergillosis requires a high degree of clinical suspicion, because there are no typical clinical symptoms or CSF findings. Clinical features are usually dramatic and tend to progress rapidly. Changes in mental status, hemiparesis and seizures are most common, but other nonspecific neurological features may occur and should always be an indication for neuroradiological examination in high-risk patients, in order to allow early initiation of antifungal therapy. Low density lesions with little or no mass effect and minimal or no contrast enhancement on CT scans that are usually more numerous on MRI and show intermediate signal intensity within high-signal areas on T2-weighted images, may suggest CNS aspergillosis. Cerebral lesions in CNS aspergillosis are often located not only in the cerebral hemispheres but also in the basal ganglia, thalami, corpus callosum and perforator artery territories. There is frequently a lack of contrast enhancement or perifocal oedema, due to the immunosuppressed status of the patient. A definite diagnosis requires brain tissue for histopathological analysis. However, neurosurgery is often not feasible, so that any of the neuroradiological findings mentioned above should raise the suspicion of CNS aspergillosis in immunocompromised patients and lead to early initiation of antifungal therapy. In the past, amphotericin B-based therapy was the treatment of choice for CNS aspergillosis, but this treatment produced negligible effects. Recently, voriconazole has been reported to be more effective than amphotericin B in the treatment of invasive aspergillosis. Response rates of about 35% have been achieved with voriconazole in patients with CNS aspergillosis. Combination therapy with antifungal agents, such as voriconazole plus caspofungin or liposomal amphotericin B, is being investigated in vitro and in animal models, and optimistic results have been observed. A combined medical and neurosurgical treatment should be considered in all patients with this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.