ArticleProceedings of the National Academy of Sciences of the United States of America1991
Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation.PLoS pathogens · 2017Article
- DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish.Journal of hematology & oncology · 2015Article
- DNA methylation dynamics in health and disease.Nature structural & molecular biology · 2013Review
- Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration.Developmental biology · 2009Article
- Overexpression of 5-methylcytosine DNA glycosylase in human embryonic kidney cells EcR293 demethylates the promoter of a hormone-regulated reporter gene.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- 5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation.Molecular and cellular biology · 1999Article
- Methylation similarities of two CpG sites within exon 5 of human H19 between normal tissues and testicular germ cell tumours of adolescents and adults, without correlation with allelic and total level of expression.British journal of cancer · 1997Article
- Dynamic methylation adjustment and counting as part of imprinting mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The initiation of de novo methylation of foreign DNA integrated into a mammalian genome is not exclusively targeted by nucleotide sequence.Journal of virology · 1995Article
- Alu repeated DNAs are differentially methylated in primate germ cells.Nucleic acids research · 1994Article
- Methylation profiles of genomic DNA of mouse developmental brain detected by restriction landmark genomic scanning (RLGS) method.Nucleic acids research · 1993Article
- Mechanistic aspects of genome-wide demethylation in the preimplantation mouse embryo.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.The EMBO journal · 1993Article
- Demethylation of somatic and testis-specific histone H2A and H2B genes in F9 embryonal carcinoma cells.Molecular and cellular biology · 1993Article
- Developmental differences in methylation of human Alu repeats.Molecular and cellular biology · 1993Article
- Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here a detailed study of developmental changes in the methylation status of specific sites in a single-copy tissue-specific gene, from the germ cell through the early embryo to adult tissues. Two sites at the 5' end of the mouse apolipoprotein AI gene were unmethylated in the ovulated unfertilized oocytes and methylated in the sperm. In contrast, a third site, located upstream of the gene, was methylated and a CpG island within the gene was unmethylated in both oocyte and sperm. The methylated sites, regardless of maternal or paternal origin, underwent demethylation in the early embryo (8-16 cells) and stayed unmethylated through the late blastocyst stage. During gastrulation, non-CpG island sites underwent methylation, followed by gradual demethylation at specific sites in tissues parallel to expression of the gene (liver and intestine). The formation of the mature tissue-specific methylation pattern of the apolipoprotein AI gene, therefore, involves the following three major events: (i) erasure of the germ-cell methylation pattern (at the 8- to 16-cell stage), (ii) formation of a new methylation pattern by de novo methylation of non-CpG island sites (during gastrulation), and (iii) tissue-specific demethylation associated with the onset of expression of the gene.
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