ReviewSchizophrenia bulletin2007
Dopamine genes and schizophrenia: case closed or evidence pending?
Review in Schizophrenia bulletin, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders.Translational psychiatry · 2022Pooled it
- Epigenetic Regulation in Schizophrenia: Focus on Methylation and Histone Modifications in Human Studies.Genes · 2024Review
- Prenatal stress induced chromatin remodeling and risk of psychopathology in adulthood.International review of neurobiology · 2021Article
- The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Theranostic Biomarkers for Schizophrenia.International journal of molecular sciences · 2017Review
- Evaluating the dopamine hypothesis of schizophrenia in a large-scale genome-wide association study.Schizophrenia research · 2016Article
- Beyond main effects of gene-sets: harsh parenting moderates the association between a dopamine gene-set and child externalizing behavior.Brain and behavior · 2016Article
- Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample.Schizophrenia research · 2013Article
- Association between ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients.Behavioral and brain functions : BBF · 2012Article
- Genetic association studies of antioxidant pathway genes and schizophrenia.Antioxidants & redox signaling · 2011Review
- Associations between psychotic-like symptoms and inattention/hyperactivity symptoms.Social psychiatry and psychiatric epidemiology · 2011Article
- Fine-mapping reveals novel alternative splicing of the dopamine transporter.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Genetic repositories for the study of major psychiatric conditions: what do we know about ethnic minorities' genetic vulnerability?Molecular psychiatry · 2010Article
- Candidate genes and their interactions with other genetic/environmental risk factors in the etiology of schizophrenia.Brain research bulletin · 2010Review
- Dopaminergic dysfunction in schizophrenia: salience attribution revisited.Schizophrenia bulletin · 2010Review
- Schizophrenia: from genes to phenes to disease.Current psychiatry reports · 2008Review
- A network of dopaminergic gene variations implicated as risk factors for schizophrenia.Human molecular genetics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The dopamine hypothesis of schizophrenia (SZ) has motivated a large number of genetic association studies but few if any dopaminergic (DA) polymorphisms are accepted as credible risk factors at present. To evaluate whether dopamine-related genes have been investigated adequately, we surveyed public genetic databases and published SZ association studies with regard to 14 conventional DA genes and 7 selected dopamine-interacting proteins. We estimate that 325 polymorphisms would be required to evaluate the impact of common variation on SZ risk among Caucasian samples. To date, 98 polymorphisms have been analyzed in published association studies. We estimate that only 19 of these variations have been evaluated in samples with at least 50% power to detect an association of the effect size commonly found in genetically complex disorders. While it is possible that DA genes do not harbor genetic risk factors for SZ, our review suggests that satisfactory conclusions for most genes cannot be drawn at present. Whole-genome association studies have begun to fill this void, but additional analyses are likely to be needed. Recommendations for future association studies include analysis of adequately powered samples, judiciously selected polymorphisms, multiple ethnic groups, and concurrent evaluation of function at associated single-nucleotide polymorphisms.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.