Evidence map›Paper›PMID 17630338›Full record

ReviewClinical microbiology reviews2007

Laboratory diagnostic techniques for Entamoeba species.

R Fotedar, D Stark, N Beebe, D Marriott, J Ellis, J Harkness

Open access · greenAbstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed, 6 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

181 citing papers in PubMed, 6 syntheses or guidelines pooled it, 464 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Systematic Review of Brain-Eating Amoeba: A Decade Update.International journal of environmental research and public health · 2023
    Pooled it
  4. Antiamoebic drugs for treating amoebic colitis.The Cochrane database of systematic reviews · 2019
    Pooled it
  5. Pooled it
  6. Colonoscopic diagnosis of amebiasis: a case series and systematic review.International journal of colorectal disease · 2015
    Pooled it
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Evaluation of Each ThreeMicroorganisms · 2025
    Article
  19. Genotypic characterization ofFood and waterborne parasitology · 2025
    Article
  20. Article

121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

R FotedarSt. Vincent's Hospital, Department of Microbiology, Sydney, Darlinghurst, NSW 2010, Australia.
D Stark
N Beebe
D Marriott
J Ellis
J Harkness
St Vincent's Hospital · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genus Entamoeba contains many species, six of which (Entamoeba histolytica, Entamoeba dispar, Entamoeba moshkovskii, Entamoeba polecki, Entamoeba coli, and Entamoeba hartmanni) reside in the human intestinal lumen. Entamoeba histolytica is the causative agent of amebiasis and is considered a leading parasitic cause of death worldwide in humans. Although recent studies highlight the recovery of E. dispar and E. moshkovskii from patients with gastrointestinal symptoms, there is still no convincing evidence of a causal link between the presence of these two species and the symptoms of the host. New approaches to the identification of E. histolytica are based on detection of E. histolytica-specific antigen and DNA in stool and other clinical samples. Several molecular diagnostic tests, including conventional and real-time PCR, have been developed for the detection and differentiation of E. histolytica, E. dispar, and E. moshkovskii in clinical samples. The purpose of this review is to discuss different methods that exist for the identification of E. histolytica, E. dispar, and E. moshkovskii which are available to the clinical diagnostic laboratory. To address the need for a specific diagnostic test for amebiasis, a substantial amount of work has been carried out over the last decade in different parts of the world. The molecular diagnostic tests are increasingly being used for both clinical and research purposes. In order to minimize undue treatment of individuals infected with other species of Entamoeba such as E. dispar and E. moshkovskii, efforts have been made for specific diagnosis of E. histolytica infection and not to treat based simply on the microscopic examination of Entamoeba species in the stool. The incorporation of many new technologies into the diagnostic laboratory will lead to a better understanding of the public health problem and measures to control the disease.

Indexed as

AnimalsAntibodies, ProtozoanAntigens, ProtozoanChromatographyDNA, ProtozoanEntamoebaEntamoebiasisEnzyme-Linked Immunosorbent AssayHumansIsoenzymesNucleic Acid Amplification TechniquesOligonucleotide Array Sequence AnalysisPolymerase Chain ReactionProtozoan ProteinsAntibodies, ProtozoanAntigens, ProtozoanDNA, ProtozoanIsoenzymesProtozoan Proteins

Identifiers

PMID17630338
PMCPMC1932757
OpenAlexW2133290730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.