ReviewClinical microbiology reviews2007
Carbapenemases: the versatile beta-lactamases.
Review in Clinical microbiology reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,127 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1,127 citing papers in PubMed, 5 syntheses or guidelines pooled it, 2,447 citations in OpenAlex.
- Risk factors for carbapenem-resistantFrontiers in public health · 2026Pooled it
- Drug-resistantClinical microbiology reviews · 2025Pooled it
- A systematic review and individual bacterial species level meta-analysis of in vitro studies on the efficacy of ceftazidime/avibactam combined with other antimicrobials against carbapenem-resistant Gram-negative bacteria.The Journal of antimicrobial chemotherapy · 2025Pooled it
- Pooled it
- Systematic review of multidrug-resistantFrontiers in microbiology · 2025Pooled it
- Carbapenemase-producingEmerging microbes & infections · 2026Article
- Global epidemiology of carbapenem-resistantJAC-antimicrobial resistance · 2026Review
- Pharmaceutical innovation in advanced nanomedicine for the treatment of hypervirulent and multidrug-resistant Klebsiella pneumoniae infections.Archives of microbiology · 2026Review
- Plasmid-mediated dissemination ofMicrobiology spectrum · 2026Article
- Development of Loop-Mediated Isothermal Amplification with a Lateral Flow Dipstick for Detection of theInternational journal of molecular sciences · 2026Article
- Dynamical-nonequilibrium alanine scanning for identifying allosteric positions in proteins.Biophysical journal · 2026Article
- The Effects of Exogenous Glutathione on β-lactam Susceptibility in New Delhi Metallo-β-Lactamase (NDM-1) Producing Klebsiella pneumoniae.Current microbiology · 2026Article
- Zinc displacement and metabolic interference: cobalt ion-mediated therapy for broad-spectrum CRKP-resistant pneumonia via inhalable microspheres.Nature communications · 2026Article
- Plasma and intrapulmonary pharmacokinetics of funobactam, a novel diazabicyclooctane β-lactamase inhibitor, administered in combination with imipenem/cilastatin in healthy subjects.Antimicrobial agents and chemotherapy · 2026Article
- Whole-genome sequencing analysis of clinical carbapenemase-producing bacteria isolated in Dakar, Senegal.Microbiology spectrum · 2026Article
- Evaluation of BD Phoenix CPO Detect and NG-Test CARBA 5 for the detection and classification of carbapenemase-producingMicrobiology spectrum · 2026Article
- One Health transmission of plasmid-mediated antimicrobial resistance: genomic insights at the interface of food, animals, humans and the environment.JAC-antimicrobial resistance · 2026Review
- Carbapenemase type-dependent pharmacodynamic activity of minocycline-biapenem combination against carbapenemase-producingJAC-antimicrobial resistance · 2026Article
- Synergistic eradication of NDM-1Materials today. Bio · 2026Article
- Occurrence of multidrug-resistant bacteria and clinically important β-lactamase resistance genes in giant freshwater prawn (<em>Macrobrachium rosenbergii</em>) aquaculture ponds in Thailand.Veterinary world · 2026Article
1,067 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbapenemases are beta-lactamases with versatile hydrolytic capacities. They have the ability to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria producing these beta-lactamases may cause serious infections in which the carbapenemase activity renders many beta-lactams ineffective. Carbapenemases are members of the molecular class A, B, and D beta-lactamases. Class A and D enzymes have a serine-based hydrolytic mechanism, while class B enzymes are metallo-beta-lactamases that contain zinc in the active site. The class A carbapenemase group includes members of the SME, IMI, NMC, GES, and KPC families. Of these, the KPC carbapenemases are the most prevalent, found mostly on plasmids in Klebsiella pneumoniae. The class D carbapenemases consist of OXA-type beta-lactamases frequently detected in Acinetobacter baumannii. The metallo-beta-lactamases belong to the IMP, VIM, SPM, GIM, and SIM families and have been detected primarily in Pseudomonas aeruginosa; however, there are increasing numbers of reports worldwide of this group of beta-lactamases in the Enterobacteriaceae. This review updates the characteristics, epidemiology, and detection of the carbapenemases found in pathogenic bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.