ArticleRNA (New York, N.Y.)2007
Influence of C-5 halogenation of uridines on hairpin versus duplex RNA folding.
Article in RNA (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- On the Importance of Halogen and Chalcogen Bonds in the Solid State of Nucleic Acids: A Combined Crystallographic and Theoretical Perspective.International journal of molecular sciences · 2023Article
- A Comprehensive Ab Initio Study of Halogenated A···U and G···C Base Pair Geometries and Energies.International journal of molecular sciences · 2023Article
- Engineering Crystal Packing in RNA Structures I: Past and Future Strategies for Engineering RNA Packing in Crystals.Crystals · 2021Article
- A Combined Experimental and Computational Study of Halogen and Hydrogen Bonding in Molecular Salts of 5-Bromocytosine.Molecules (Basel, Switzerland) · 2021Article
- An atlas of RNA base pairs involving modified nucleobases with optimal geometries and accurate energies.Nucleic acids research · 2015Article
- RNA dimerization monitored by fluorescence correlation spectroscopy.European biophysics journal : EBJ · 2011Article
- A fast selenium derivatization strategy for crystallization and phasing of RNA structures.RNA (New York, N.Y.) · 2009Article
- Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs.RNA (New York, N.Y.) · 2008Article
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Authors and funding
4 authors.
Funding
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Abstract
Halogenation of bases is a widespread method used for solving crystal structures of nucleic acids. However, this modification may have important consequences on RNA folding and thus on the success of crystallization. We have used a combination of UV thermal melting, steady-state fluorescence, X-ray crystallography, and gel electrophoresis techniques to study the influence of uridine halogenation (bromination or iodination) on the RNA folding. The HIV-1 Dimerization Initiation Site is an RNA hairpin that can adopt an alternative duplex conformation and was used as a model. We have shown that, unexpectedly, the RNA hairpin/duplex ratio is strongly dependent not only on the presence but also on the position of halogenation.
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