ArticleApplied and environmental microbiology2007
Analysis of a ferric uptake regulator (Fur) mutant of Desulfovibrio vulgaris Hildenborough.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 76 citations in OpenAlex.
- The dual role of TonB genes in turnerbactin uptake and carbohydrate utilization in the shipworm symbiontApplied and environmental microbiology · 2023Article
- Genomic insight into iron acquisition by sulfate-reducing bacteria in microaerophilic environments.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
- Text-Mining to Identify Gene Sets Involved in Biocorrosion by Sulfate-Reducing Bacteria: A Semi-Automated Workflow.Microorganisms · 2023Article
- Article
- Deletion Mutants, Archived Transposon Library, and Tagged Protein Constructs of the Model Sulfate-Reducing Bacterium Desulfovibrio vulgaris Hildenborough.Microbiology resource announcements · 2021Article
- Article
- Experimental evolution reveals nitrate tolerance mechanisms in Desulfovibrio vulgaris.The ISME journal · 2020Article
- Article
- Functional Analysis of the Ferric Uptake Regulator Gene fur in Xanthomonas vesicatoria.PloS one · 2016Article
- The iron stimulon and fur regulon of Geobacter sulfurreducens and their role in energy metabolism.Applied and environmental microbiology · 2014Article
- Genetic basis for nitrate resistance in Desulfovibrio strains.Frontiers in microbiology · 2014Article
- Identification and characterization of novel Helicobacter pylori apo-fur-regulated target genes.Journal of bacteriology · 2013Article
- Flexibility of syntrophic enzyme systems in Desulfovibrio species ensures their adaptation capability to environmental changes.Journal of bacteriology · 2013Article
- Characterization of NaCl tolerance in Desulfovibrio vulgaris Hildenborough through experimental evolution.The ISME journal · 2013Article
- Regulation of iron metabolism by Pyrococcus furiosus.Journal of bacteriology · 2013Article
- Variation among Desulfovibrio species in electron transfer systems used for syntrophic growth.Journal of bacteriology · 2013Article
- The regulatory role of ferric uptake regulator (Fur) during anaerobic respiration of Shewanella piezotolerans WP3.PloS one · 2013Article
- Partial associations of dietary iron, smoking and intestinal bacteria with colorectal cancer risk.Nutrition and cancer · 2013Article
- Deletion of the Desulfovibrio vulgaris carbon monoxide sensor invokes global changes in transcription.Journal of bacteriology · 2012Article
- Novel iron-regulated and Fur-regulated small regulatory RNAs in Aggregatibacter actinomycetemcomitans.Molecular oral microbiology · 2012Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous experiments examining the transcriptional profile of the anaerobe Desulfovibrio vulgaris demonstrated up-regulation of the Fur regulon in response to various environmental stressors. To test the involvement of Fur in the growth response and transcriptional regulation of D. vulgaris, a targeted mutagenesis procedure was used for deleting the fur gene. Growth of the resulting Deltafur mutant (JW707) was not affected by iron availability, but the mutant did exhibit increased sensitivity to nitrite and osmotic stresses compared to the wild type. Transcriptional profiling of JW707 indicated that iron-bound Fur acts as a traditional repressor for ferrous iron uptake genes (feoAB) and other genes containing a predicted Fur binding site within their promoter. Despite the apparent lack of siderophore biosynthesis genes within the D. vulgaris genome, a large 12-gene operon encoding orthologs to TonB and TolQR also appeared to be repressed by iron-bound Fur. While other genes predicted to be involved in iron homeostasis were unaffected by the presence or absence of Fur, alternative expression patterns that could be interpreted as repression or activation by iron-free Fur were observed. Both the physiological and transcriptional data implicate a global regulatory role for Fur in the sulfate-reducing bacterium D. vulgaris.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.