ArticleMammalian genome : official journal of the International Mammalian Genome Society2007
Neurobehavioral mutants identified in an ENU-mutagenesis project.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- OpenStats: A robust and scalable software package for reproducible analysis of high-throughput phenotypic data.PloS one · 2020Article
- Article
- New insights into behaviour using mouse ENU mutagenesis.Human molecular genetics · 2012Review
- Robust and sensitive analysis of mouse knockout phenotypes.PloS one · 2012Article
- Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders.Current topics in behavioral neurosciences · 2012Review
- The clinical implications of mouse models of enhanced anxiety.Future neurology · 2011Article
- High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains.Genes, brain, and behavior · 2010Article
- Linking genetically defined neurons to behavior through a broadly applicable silencing allele.Neuron · 2009Article
- Evaluation of animal models of neurobehavioral disorders.Behavioral and brain functions : BBF · 2009Article
- Progress in genetic studies of pain and analgesia.Annual review of pharmacology and toxicology · 2009Review
- A new mouse mutant for the LDL receptor identified using ENU mutagenesis.Journal of lipid research · 2008Article
- Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines.Pharmacology, biochemistry, and behavior · 2008Article
- A high through-put reverse genetic screen identifies two genes involved in remote memory in mice.PloS one · 2008Article
- From ENU mutagenesis to population genetics.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
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7 authors.
Funding
Abstract
We report on a battery of behavioral screening tests that successfully identified several neurobehavioral mutants among a large-scale ENU-mutagenized mouse population. Large numbers of ENU-mutagenized mice were screened for abnormalities in central nervous system function based on abnormal performance in a series of behavior tasks. We developed and used a high-throughput screen of behavioral tasks to detect behavioral outliers. Twelve mutant pedigrees, representing a broad range of behavioral phenotypes, have been identified. Specifically, we have identified two open-field mutants (one displaying hyperlocomotion, the other hypolocomotion), four tail-suspension mutants (all displaying increased immobility), one nociception mutant (displaying abnormal responsiveness to thermal pain), two prepulse inhibition mutants (displaying poor inhibition of the startle response), one anxiety-related mutant (displaying decreased anxiety in the light/dark test), and one learning-and-memory mutant (displaying reduced response to the conditioned stimulus). These findings highlight the utility of a set of behavioral tasks used in a high-throughput screen to identify neurobehavioral mutants. Further analysis (i.e., behavioral and genetic mapping studies) of mutants is in progress with the ultimate goal of identification of novel genes and mouse models relevant to human disorders as well as the identification of novel therapeutic targets.
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