ArticleMechanisms of development2007
Compensational regulation of bHLH transcription factors in the postnatal development of BETA2/NeuroD1-null retina.
Article in Mechanisms of development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Overexpressing neurogenic differentiation factor 1 in Müller cells improves retinal function after optic nerve crush injury in adult mice.Neural regeneration research · 2026Article
- Recent progress of principal techniques used in the study of Müller glia reprogramming in mice.Cell regeneration (London, England) · 2024Review
- The Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell adhesion and motility.Cell death discovery · 2023Article
- Overexpressing NeuroD1 reprograms Müller cells into various types of retinal neurons.Neural regeneration research · 2023Article
- Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development.Frontiers in molecular neuroscience · 2023Review
- Circuit formation in the adult brain.The European journal of neuroscience · 2022Review
- Glucocorticoid and Mineralocorticoid Receptors in the Brain: A Transcriptional Perspective.Journal of the Endocrine Society · 2019Review
- Effects of Subretinal Gene Transfer at Different Time Points in a Mouse Model of Retinal Degeneration.PloS one · 2016Article
- Ophthalmological phenotype associated with homozygous null mutation in the NEUROD1 gene.Molecular vision · 2015Article
- Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration.Journal of lipid research · 2013Article
- Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene.Experimental eye research · 2013Article
- Progenitor cell capacity of NeuroD1-expressing globose basal cells in the mouse olfactory epithelium.The Journal of comparative neurology · 2011Article
- Candidate genes for panhypopituitarism identified by gene expression profiling.Physiological genomics · 2011Article
- Methods for lymphatic vessel culture and gene transfection.Microcirculation (New York, N.Y. : 1994) · 2009Article
- Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The bHLH transcriptional factor BETA2/NeuroD1 is essential for the survival of photoreceptor cells in the retina. Although this gene is expressed throughout the retina, BETA2/NeuroD1 knockout mice show photoreceptor cell degeneration only in the outer nuclear layer of the retina; other retinal neurons are not affected. Previous studies on retina explants lacking three bHLH genes revealed that retinal neurons in the inner nuclear layer require multiple bHLH genes for their differentiation and survival. However, single- or double-gene mutations show no or a lesser degree of abnormalities during eye development, likely because of compensation or cooperative regulation among those genes. Because not all null mice survive until the retina is fully organized, no direct evidence of this concept has been reported. To understand the regulatory mechanisms between bHLH factors in retinal development, we performed a detailed analysis of BETA2/NeuroD1 knockout mice. BETA2/NeuroD1 was expressed in all 3 layers of the mouse retina, including all major types of neurons. In addition, a null mutation of BETA2/NeuroD1 resulted in up-regulation of other bHLH genes, Mash1, Neurogenin2, and Math3, in the inner nuclear layer. Our data suggest that compensatory and cross regulatory mechanisms exist among the bHLH factors during retinal development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.