ArticleNeuroscience2007
Androgen and estrogen receptor-mediated mechanisms of testosterone action in male rat pelvic autonomic ganglia.
Article in Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Effect of Testosterone on Maintenance of Morphine-induced Conditioned Place Preference: Androgen and μ-opioid Receptor Gene Expressions in PFC and NAc of Rats.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- The Anatomy, Histology, and Function of the Major Pelvic Ganglion.Animals : an open access journal from MDPI · 2024Review
- Involvement of D2-like dopaminergic receptors in contextual fear conditioning in female rats: influence of estrous cycle.Frontiers in behavioral neuroscience · 2022Article
- The Effect of Castration on Peripheral Autonomic Neurons Supplying Mammalian Male Genitourinary System.International journal of molecular sciences · 2021Review
- Endometritis decreases the population of uterine neurons in the paracervical ganglion and changes the expression of sympathetic neurotransmitters in sexually mature gilts.BMC veterinary research · 2021Article
- Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand.International journal of environmental research and public health · 2021Article
- Neurophysiological control of urinary bladder storage and voiding-functional changes through development and pathology.Pediatric nephrology (Berlin, Germany) · 2021Review
- Dissection of Pelvic Autonomic Ganglia and Associated Nerves in Male and Female Rats.Journal of visualized experiments : JoVE · 2020Article
- Sex differences in lower urinary tract biology and physiology.Biology of sex differences · 2018Review
- Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and the GDNF Family Receptor Alpha Subunit 1 in the Paravaginal Ganglia of Nulliparous and Primiparous Rabbits.International neurourology journal · 2018Article
- Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits.BioMed research international · 2017Article
- Serotonin Receptor 5-HT3A Affects Development of Bladder Innervation and Urinary Bladder Function.Frontiers in neuroscience · 2017Article
- Translational Perspective on the Role of Testosterone in Sexual Function and Dysfunction.The journal of sexual medicine · 2016Review
- Effect of testosterone therapy on the urinary bladder in experimental hypogonadism of rats.Journal of molecular histology · 2015Article
- The effects of early versus delayed castration targeting androgen on prolonging survival in a mouse model of bladder cancer.International journal of clinical and experimental pathology · 2015Article
- Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway.PloS one · 2014Article
- Long-term estradiol-17β administration changes the population of paracervical ganglion neurons supplying the ovary in adult gilts.Journal of molecular neuroscience : MN · 2013Article
- Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra.BMC neuroscience · 2012Article
- Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia.Journal of neuroscience research · 2009Article
- Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice.BMC developmental biology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Although male reproductive function is primarily androgen dependent, many studies suggest that estrogens have direct actions on the male reproductive organs. Pelvic autonomic neurons provide the motor control of the internal reproductive organs and the penis and various properties of these neurons are affected by endogenous androgens. However, the possible role of estrogens at this site has not been examined. Here we have investigated the significance of estrogens produced by aromatization of testosterone (T) in the physiological actions of androgens on adult male rat pelvic ganglion neurons. Reverse transcriptase polymerase chain reaction (RT-PCR) studies showed that aromatase and both estrogen receptors (ERalpha and ERbeta) are expressed in these ganglia. Western blotting also showed that aromatase is expressed in male pelvic ganglia. Using immunohistochemical visualization, ERalpha was predominantly expressed by nitric oxide synthase (NOS)-positive parasympathetic pelvic ganglion neurons. In vivo studies showed that the decrease in pelvic ganglion soma size caused by gonadectomy could be prevented by administration of T or dihydrotestosterone (DHT), but not 17beta-estradiol (E2), showing that this maintenance action of testosterone is mediated entirely by androgenic mechanisms. However, in vitro studies of cultured pelvic ganglion neurons revealed that T, DHT and E each stimulated the growth of longer and more complex neurites in both noradrenergic and cholinergic NOS-expressing neurons. The effects of T were attenuated by either androgen or estrogen receptor antagonists, or by inhibition of aromatase. Together these studies demonstrate that estrogens are likely to be synthesized in the male pelvic ganglia, produced from T by local aromatase. The effects of androgens on axonal growth are likely to be at least partly mediated by estrogenic mechanisms, which may be important for understanding disease-, aging- and injury-induced plasticity in this part of the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.