ArticleJournal of cancer research and clinical oncology2008
Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance.
Article in Journal of cancer research and clinical oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Development and temporal validation of preoperative and combined preoperative-pathological models for lymph node metastasis in early gastric cancer.Frontiers in oncology · 2026Article
- Roles of Macrophage Migration Inhibitory Factor (MIF) Signaling Pathway in Oncovirus Infection and Virus-Associated Cancers.Viruses · 2025Review
- First clinical investigation to predict lymphovascular and/or perineural invasion in gastric cancer usingEuropean journal of nuclear medicine and molecular imaging · 2025Article
- Prognostic impact and reasons for variability by tumor location in gastric cancer.World journal of gastroenterology · 2024Article
- Correlation between postoperative chemotherapy regimen and survival in patients with resectable gastric adenocarcinoma accompanied with vascular cancer thrombus.World journal of gastrointestinal surgery · 2024Article
- Analysis of enhanced CT imaging signs and clinicopathological prognostic factors in hepatoid adenocarcinoma of stomach patients with radical surgery: a retrospective study.BMC medical imaging · 2023Article
- Matrix metalloproteinase‑1 expression is regulated by HIF‑1‑dependent and epigenetic mechanisms and serves a tumor‑suppressive role in gastric cancer progression.International journal of oncology · 2021Article
- Tumor cell invasion in blood vessels assessed by immunohistochemistry is related to decreased survival in patients with bladder cancer treated with radical cystectomy.Diagnostic pathology · 2021Article
- Prognostic significance of Borrmann type combined with vessel invasion status in advanced gastric cancer.World journal of gastrointestinal oncology · 2020Article
- Lymphatic Invasion Might Be Considered as an Upstaging Factor in N0 and N1 Gastric Cancer.Journal of clinical medicine · 2020Article
- Association between Lymphovascular Invasion and Recurrence in Patients with pT1N+ or pT2-3N0 Gastric Cancer: a Multi-institutional Dataset Analysis.Journal of gastric cancer · 2020Article
- Prognostic factors for survival in patients with gastric cancer: Single-centre experience.Northern clinics of Istanbul · 2020Article
- Retrospective evaluation of lymphatic and blood vessel invasion and Borrmann types in advanced proximal gastric cancer.World journal of gastrointestinal oncology · 2019Article
- Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations.World journal of gastroenterology · 2019Article
- Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer.Journal of gastrointestinal oncology · 2017Article
- Impact of capillary invasion on the prognosis of gastric adenocarcinoma patients: A retrospective cohort study.Oncotarget · 2016Article
- The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China.BMC cancer · 2015Article
- Vascular invasion as an independent predictor of poor prognosis in nonmetastatic gastric cancer after curative resection.International journal of clinical and experimental pathology · 2015Article
- Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome.BMC cancer · 2014Article
- N,N'-dinitrosopiperazine-mediated AGR2 is involved in metastasis of nasopharyngeal carcinoma.PloS one · 2014Article
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10 authors.
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Abstract
backgroundLymphatic and/or blood vessel tumoral invasion (LBVI) is a common histopathologic finding of gastric carcinomas, which could make it an additional cost efficient marker and help in the detection of patients at risk for recurrence. MATERIALS AND
methodsThe subjects of this study were 144 patients with primary gastric adenocarcinoma, who consecutively underwent surgery. LBVI was evaluated by H&E staining and complementary with immunohistochemical staining with anti-CD34. Intratumoral levels of EGFR were analyzed with a radioligand technique, whereas c-erbB-2 and tPA were determined by ELISA methods; pS2, cathepsin D and hyaluronic acid by immunoradiometric assays; and VEGFR-1 and -2 by immunohistochemical assays. The mean follow-up period for these patients was 33.1 months.
resultsLBVI was present in 46 patients (31.9%). The presence of LBVI correlated significantly with tumor stage, lymph node involvement, surgical resectability, histological type and histological grade, being present in a higher percentage among II-IV tumor stage (P = 0.0001), poorly differentiated (P = 0.01), diffuse type (P = 0.009), R1-R2 (P = 0.002) and lymph node-positive (P = 0.005) tumors. In addition, statistical analysis demonstrated that LBVI was significantly associated with a poorer overall patients' survival in the univariate analysis (P = 0.0001) as well as in the multivariate analysis (P = 0.009). However, our results failed to show any significant relationship between LBVI and any of the intratumoral biological parameters studied.
conclusionLBVI provides additional useful information that could be applied to identify gastric cancer patients at risk for recurrence, who might be candidates for further adjuvant therapies.
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