Trial reportPsychopharmacology2007
Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing.
Trial report in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How do lipids influence risk of violence, self-harm and suicidality in people with psychosis? A systematic review.The Australian and New Zealand journal of psychiatry · 2022Pooled it
- The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men.Neuroscience letters · 2010Trial
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study.Acta neuropsychiatrica · 2026Review
- Review
- The 21-item Barratt Impulsiveness Scale Revised (BIS-R-21): An alternative three-factor model.Journal of behavioral addictions · 2020Article
- Moderation of the relationship between Toxoplasma gondii seropositivity and trait impulsivity in younger men by the phenylalanine-tyrosine ratio.Psychiatry research · 2018Article
- Disentangling the genetic overlap between cholesterol and suicide risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Prevalence of hypobetalipoproteinemia and related psychiatric characteristics in a psychiatric population: results from the retrospective HYPOPSY Study.Lipids in health and disease · 2018Article
- Individual biological sensitivity to environmental influences: testing the differential susceptibility properties of the 5HTTLPR polymorphism in relation to depressive symptoms and delinquency in two adolescent general samples.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.Psychiatry research · 2018Article
- Associations between serotonin transporter and behavioral traits and diagnoses related to anxiety.Psychiatry research · 2017Article
- Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms.BMC psychiatry · 2017Review
- The influence of the serotonergic system on the personality and quality of life of postmenopausal women.Clinical interventions in aging · 2017Article
- The Association Between Breastfeeding Exposure and Duration, Neuropsychological Deficits, and Psychopathic Personality Traits in Offspring: The Moderating Role of 5HTTLPR.The Psychiatric quarterly · 2016Article
- Analysis of personality traits and their influence on the quality of life of postmenopausal women with regard to genetic factors.Annals of general psychiatry · 2016Article
- A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors.Journal of community genetics · 2016Article
- The assessment of the relationship between personality, the presence of the 5HTT and MAO-A polymorphisms, and the severity of climacteric and depressive symptoms in postmenopausal women.Archives of women's mental health · 2015Article
- Influence of Altered Hormonal Status on Platelet 5-HT and MAO-B Activity in Cigarette Smokers.Indian journal of clinical biochemistry : IJCB · 2015Article
- The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development.Progress in neuro-psychopharmacology & biological psychiatry · 2014Article
- Polymorphisms in the 5-HTTLPR gene mediate storage capacity of visual working memory.Journal of cognitive neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleLow capacity of the central serotonergic system has been associated with impulsive behaviour. Both low platelet monoamine oxidase (MAO) activity and the short (S) allele of the serotonin transporter gene promoter region polymorphism (5-HTTLPR) are proposed to be markers of less efficient serotonergic functioning.
objectivesThe effect of the two markers for serotonin system efficiency on performance in a visual comparison task (VCT) and self-reported impulsiveness (Barratt Impulsiveness Scale, BIS-11) were investigated in healthy adolescents participating in the Estonian Children Personality Behaviour and Health Study. Possible confounding effect of general cognitive abilities on the performance in VCT was controlled for.
resultsLow platelet MAO activity and carrying of the S allele of 5-HTTLPR were both associated with higher error-rate and more impulsive performance in VCT. Platelet MAO activity and 5-HTTLPR S allele had a significant interactive effect on self-reported impulsivity (BIS-11). The effect of platelet MAO activity on both self-reported and performance impulsivity was significant only in the S allele carriers. The effect of 5-HTTLPR S allele on impulsive performance remained significant after controlling for general cognitive abilities.
conclusionsThe two markers of lower serotonergic capacity, 5-HTTLPR S allele and low platelet MAO activity, have a similar and partly synergistic influence on self-reported as well as performance measures of impulsivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.