ArticleThe EMBO journal2007
HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 47 citations in OpenAlex.
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- Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila.Nature genetics · 2026Article
- HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs.Cell reports · 2026Article
- Telomeric RNA and HP1α form interfacial clusters that stabilize HP1α-DNA condensates.Communications biology · 2025Article
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- Unphosphorylated STAT3 in heterochromatin formation and tumor suppression in lung cancer.BMC cancer · 2020Article
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- PHF2 histone demethylase prevents DNA damage and genome instability by controlling cell cycle progression of neural progenitors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control.Science advances · 2019Article
- Chromatin organization changes during the establishment and maintenance of the postmitotic state.Epigenetics & chromatin · 2017Article
- SUMOylation of HP1α supports association with ncRNA to define responsiveness of breast cancer cells to chemotherapy.Oncotarget · 2016Article
- Epigenetics in NG2 glia cells.Brain research · 2016Review
- A novel role of PRR14 in the regulation of skeletal myogenesis.Cell death & disease · 2015Article
- Epigenetic regulation of cardiac myocyte differentiation.Frontiers in genetics · 2014Review
- WEE1 tyrosine kinase, a novel epigenetic modifier.Trends in genetics : TIG · 2013Review
- A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells.The Journal of cell biology · 2013Article
- Genetic and epigenetic alterations of myeloproliferative disorders.International journal of hematology · 2013Review
- Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha.PloS one · 2013Article
- Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
A critical step of neuronal terminal differentiation is the permanent withdrawal from the cell cycle that requires the silencing of genes that drive mitosis. Here, we describe that the alpha isoform of the heterochromatin protein 1 (HP1) protein family exerts such silencing on several E2F-targeted genes. Among the different isoforms, HP1alpha levels progressively increase throughout differentiation and take over HP1gamma binding on E2F sites in mature neurons. When overexpressed, only HP1alpha is able to ensure a timed repression of E2F genes. Specific inhibition of HP1alpha expression drives neuronal progenitors either towards death or cell cycle progression, yet preventing the expression of the neuronal marker microtubule-associated protein 2. Furthermore, we provide evidence that this mechanism occurs in cerebellar granule neurons in vivo, during the postnatal development of the cerebellum. Finally, our results suggest that E2F-targeted genes are packaged into higher-order chromatin structures in mature neurons relative to neuroblasts, likely reflecting a transition from a 'repressed' versus 'silenced' status of these genes. Together, these data present new epigenetic regulations orchestrated by HP1 isoforms, critical for permanent cell cycle exit during neuronal differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.