ArticleAmerican journal of respiratory and critical care medicine2007
Airway strain during mechanical ventilation in an intact animal model.
Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Association between controlled mechanical ventilation and systemic inflammation in acute hypoxemic respiratory failure: an observational cohort study.Critical care (London, England) · 2025Observational
- High Stretch Associated with Mechanical Ventilation Promotes Piezo1-Mediated Migration of Airway Smooth Muscle Cells.International journal of molecular sciences · 2024Article
- Article
- New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome.Biomolecules · 2022Review
- MircroRNA Let-7a-5p in Airway Smooth Muscle Cells is Most Responsive to High Stretch in Association With Cell Mechanics Modulation.Frontiers in physiology · 2022Article
- mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury.JCI insight · 2021Article
- Novel Mechanical Strain Characterization of VentilatedFrontiers in physiology · 2020Article
- Alveolar dynamics during mechanical ventilation in the healthy and injured lung.Intensive care medicine experimental · 2019Review
- Dynamic airway constriction in rats: heterogeneity and response to deep inspiration.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Novel analysis of 4DCT imaging quantifies progressive increases in anatomic dead space during mechanical ventilation in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Mechanisms of airway responses to esophageal acidification in cats.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Synchrotron X-ray imaging of pulmonary alveoli in respiration in live intact mice.Scientific reports · 2015Article
- A Bidirectional Coupling Procedure Applied to Multiscale Respiratory Modeling.Journal of computational physics · 2013Article
- Murine mechanical ventilation stimulates alveolar epithelial cell proliferation.Experimental lung research · 2010Article
- Airway wall stiffening increases peak wall shear stress: a fluid-structure interaction study in rigid and compliant airways.Annals of biomedical engineering · 2010Article
- Recent advances and new opportunities in lung mechanobiology.Journal of biomechanics · 2010Review
- Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1.American journal of physiology. Lung cellular and molecular physiology · 2008Article
- Airway constriction measured from tantalum bronchograms in conscious mice in response to methacholine.Journal of applied physiology (Bethesda, Md. : 1985) · 2008Article
- Airway strain during mechanical ventilation in an intact animal model.American journal of respiratory and critical care medicine · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleMechanical ventilation with large tidal volumes causes ventilator-induced lung injury in animal models. Little direct evidence exists regarding the deformation of airways in vivo during mechanical ventilation, or in the presence of positive end-expiratory pressure (PEEP).
objectivesTo measure airway strain and to estimate airway wall tension during mechanical ventilation in an intact animal model.
methodsSprague-Dawley rats were anesthetized and mechanically ventilated with tidal volumes of 6, 12, and 25 cm(3)/kg with and without 10-cm H(2)O PEEP. Real-time tantalum bronchograms were obtained for each condition, using microfocal X-ray imaging. Images were used to calculate circumferential and longitudinal airway strains, and on the basis of a simplified mathematical model we estimated airway wall tensions. MEASUREMENTS AND MAIN
resultsCircumferential and longitudinal airway strains increased with increasing tidal volume. Levels of mechanical strain were heterogeneous throughout the bronchial tree. Circumferential strains were higher in smaller airways (less than 800 mum). Airway size did not influence longitudinal strain. When PEEP was applied, wall tensions increased more rapidly than did strain levels, suggesting that a "strain limit" had been reached. Airway collapse was not observed under any experimental condition.
conclusionsMechanical ventilation results in significant airway mechanical strain that is heterogeneously distributed in the uninjured lung. The magnitude of circumferential but not axial strain varies with airway diameter. Airways exhibit a "strain limit" above which an abrupt dramatic rise in wall tension is observed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.